Age
Item
age 18 through 75
boolean
C0001779 (UMLS CUI [1])
Body mass index | Body Weight
Item
bmi between 18-40 kg/m2 and weight greater than or equal 40 kg
boolean
C1305855 (UMLS CUI [1])
C0005910 (UMLS CUI [2])
Asthma | inhaled steroids | Adrenergic beta-2 Receptor Agonists | Leukotriene Antagonists | Theophylline | Anticholinergic Agents | Chromones | Prednisone Oral Product | Exacerbation of asthma | Exacerbation of severe persistent asthma | Hospitalization
Item
documented physician-diagnosed asthma - subjects must have received a physician-prescribed asthma controller regimen with medium- or high-dose ics plus laba -if on asthma controller medications in addition to ics plus laba, the dose of the other asthma controller medications (leukotriene receptor inhibitors, theophylline, secondary ics, lama, cromones, or maintenance oral prednisone or equivalent up to a maximum of 10 mg daily or 20 mg every other day for the maintenance treatment of asthma) must be stable. -subjects must have a documented history of at least 2 asthma exacerbation events or at least 1 severe asthma exacerbation resulting in hospitalization within the 12 months prior to first study visit.
boolean
C0004096 (UMLS CUI [1])
C2065041 (UMLS CUI [2])
C2936789 (UMLS CUI [3])
C0595726 (UMLS CUI [4])
C0039771 (UMLS CUI [5])
C0242896 (UMLS CUI [6])
C0008594 (UMLS CUI [7])
C3216040 (UMLS CUI [8])
C0349790 (UMLS CUI [9])
C3508930 (UMLS CUI [10])
C0019993 (UMLS CUI [11])
Vocal Cord Dysfunction | Reactive airways dysfunction syndrome | Hyperventilation | Panic Attacks | Asthma
Item
diagnosis of vocal cord dysfunction, reactive airways dysfunction syndrome, hyperventilation and panic attacks, or other mimics of asthma.
boolean
C0859897 (UMLS CUI [1])
C1299633 (UMLS CUI [2])
C0020578 (UMLS CUI [3])
C0086769 (UMLS CUI [4])
C0004096 (UMLS CUI [5])
Current Smoker | smoking cigarettes: ____ pack-years history
Item
current smokers or subjects with a smoking history of ≥ 10 pack years
boolean
C3241966 (UMLS CUI [1])
C2230126 (UMLS CUI [2])
Former smoker | smoking cigarettes: ____ pack-years history | Stopped smoking
Item
former smokers with < 10 pack years must have stopped for at least 1 year to be eligible.
boolean
C0337671 (UMLS CUI [1,1])
C2230126 (UMLS CUI [1,2])
C0425310 (UMLS CUI [2])
Disease | Study Subject Participation Status | Limited | Chronic Obstructive Airway Disease | Cystic Fibrosis | Pulmonary Fibrosis | Bronchiectasis | Aspergillosis, Allergic Bronchopulmonary | Churg-Strauss Syndrome
Item
any concomitant respiratory disease that in the opinion of the investigator and/or medical monitor will interfere with the evaluation of the investigational product or interpretation of subject safety or study results (eg, chronic obstructive pulmonary disease, cystic fibrosis, pulmonary fibrosis, bronchiectasis, allergic bronchopulmonary aspergillosis, churg-strauss syndrome).
boolean
C0012634 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C0439801 (UMLS CUI [1,3])
C0024117 (UMLS CUI [2])
C0010674 (UMLS CUI [3])
C0034069 (UMLS CUI [4])
C0006267 (UMLS CUI [5])
C0004031 (UMLS CUI [6])
C0008728 (UMLS CUI [7])
Liver disease
Item
evidence of active liver disease.
boolean
C0023895 (UMLS CUI [1])
Malignant Neoplasms | Basal cell carcinoma | Cervix carcinoma | In situ | Tuberculosis
Item
history of cancer, except for basal cell carcinoma or insitu carcinoma of the cervix treated with apparent success with curative therapy or other malignancies are eligible provided that curative therapy was completed -known history of active tuberculosis (tb)
boolean
C0006826 (UMLS CUI [1])
C0007117 (UMLS CUI [2])
C0302592 (UMLS CUI [3,1])
C0444498 (UMLS CUI [3,2])
C0041296 (UMLS CUI [4])
Anaphylaxis | Biological Response Modifier Therapy
Item
history of anaphylaxis to any biologic therapy
boolean
C0002792 (UMLS CUI [1,1])
C0005527 (UMLS CUI [1,2])
Hepatitis B positive | Hepatitis C positive
Item
positive medical history for hepatitis b or c
boolean
C0856706 (UMLS CUI [1])
C1112419 (UMLS CUI [2])
HIV | Anti-Retroviral Agents
Item
subject with hiv or subject taking antiretroviral medications, as determined by medical history and/or subject's verbal report.
boolean
C0019682 (UMLS CUI [1])
C0599685 (UMLS CUI [2])