Age
Item
age ≤ 75 years
boolean
C0001779 (UMLS CUI [1])
ECOG
Item
ecog ≤ 3
boolean
C1520224 (UMLS CUI [1])
Acute Promyelocytic Leukemia
Item
morphologic diagnosis of lpa (fab m3 or variant m3). those cases without typical morphology but with pml-rarα reordering also must be including.
boolean
C0023487 (UMLS CUI [1])
t(15;17)(q22;q12)
Item
genetic diagnosis: t (15; 17) demonstrated by cariotipo conventional, fish, pml-rarα
boolean
C1515724 (UMLS CUI [1])
reordering detected by rt-pcr
Item
reordering detected by rt-pcr or a pattern microspeckled demonstrated with antibody anti-pml (positive pgm3). obvious, it will be had the result of these tests once initiated the treatment on the basis of a suspicion diagnoses morphologic
boolean
C2732223 (UMLS CUI [1])
Age
Item
age >75 years (the treatment with this protocol can be considered individually)
boolean
C0001779 (UMLS CUI [1])
absence of pml-rare
Item
absence of pml-rare reordering
boolean
C1366903 (UMLS CUI [1])
Chemotherapy or Retinoids
Item
to have received previously some type of treatment for lpa, including chemotherapy or retinoides. the previous treatment with corticoids, hidroxiurea or leucoaféresis is not reason for exclusion.
boolean
C3665472 (UMLS CUI [1])
C0035339 (UMLS CUI [2])
roentgenographic
Item
to have received chemotherapy or x-ray for the treatment of a disease vitiates previous
boolean
C0034571 (UMLS CUI [1])
Neoplasms
Item
associate neoplasia
boolean
C0027651 (UMLS CUI [1])
Mental disorders
Item
serious psychiatric disease
boolean
C0004936 (UMLS CUI [1])
HIV Seropositivity
Item
HIV+
boolean
C0019699 (UMLS CUI [1])
Contraindication to chemotherapy
Item
contraindication to receive intensive chemotherapy, specially antraciclinas.
boolean
C0522473 (UMLS CUI [1,1])
C3665472 (UMLS CUI [1,2])
Serum creatinine measurement
Item
Serum creatinine ≥ 2,5 mg/dl (≥ 250 μmol/l).
boolean
C0201976 (UMLS CUI [1])
Bilirubin, Alkaline phosphatase
Item
Bilirubin, fosfatasa alkaline, or got > 3 times the normal limit
boolean
C0005437 (UMLS CUI [1])
C0201850 (UMLS CUI [2])
Pregnancy test positive
Item
Positive pregnancy test
boolean
C0240802 (UMLS CUI [1])