gender; age
Item
males and females with a minimum high school education and between the ages of 50 and 90 will be selected for groups 1 and 2. for group 3, normal subjects between the ages of 20 and 49 years of age will be selected. the groups 1 and 2 will be balanced for age, and all three groups balanced for gender and apoe genotype.
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Psychotropic Drugs
Item
discontinuance of all psychotropic and/or cognitively active medication at least four weeks prior to evaluation.
boolean
C0033978 (UMLS CUI [1])
brain trauma; hydrocephalus; lacunar infarcts; seizures; mental retardation; neurological disorder
Item
past history or mri evidence of brain damage including significant trauma, stroke, hydrocephalus, lacunar infarcts, seizures, mental retardation or serious neurological disorder.
boolean
C0876926 (UMLS CUI [1])
C0020255 (UMLS CUI [2])
C0333559 (UMLS CUI [3])
C0036572 (UMLS CUI [4])
C0025362 (UMLS CUI [5])
C0027765 (UMLS CUI [6])
Substance Use Disorder
Item
significant history of alcoholism or drug abuse.
boolean
C0038586 (UMLS CUI [1])
psychiatric illness schizophrenia
Item
any history of psychiatric illness (e.g., schizophrenia, mania or depression).
boolean
C0004936 (UMLS CUI [1,1])
C0036341 (UMLS CUI [1,2])
neuropathology
Item
any focal signs or significant neuropathology.
boolean
C0876934 (UMLS CUI [1])
cerebrovascular disease; hachinski ischemia scale
Item
a score of 4 or greater on the modified hachinski ischemia scale, indicative of cerebrovascular disease.
boolean
C0007820 (UMLS CUI [1])
C0475492 (UMLS CUI [2])
hamilton depression scale
Item
a total score of 16 or more on the hamilton depression scale to exclude possible cases of primary depression.
boolean
C0451203 (UMLS CUI [1])
hypertension; cardiac disease; pulmonary disease; vascular disease; metabolic disease; hematologic disease; fasting glucose levels
Item
evidence of clinically relevant hypertensive, cardiac, pulmonary, vascular, metabolic or hematologic conditions. specific exclusion will be made for individuals with fasting glucose levels >110 mg/dl.
boolean
C0020538 (UMLS CUI [1])
C0018799 (UMLS CUI [2])
C0024115 (UMLS CUI [3])
C0042373 (UMLS CUI [4])
C0025517 (UMLS CUI [5])
C0018939 (UMLS CUI [6])
C0428568 (UMLS CUI [7])
physical impairment
Item
physical impairment of such severity as to adversely affect the validity of psychological testing.
boolean
C0231171 (UMLS CUI [1])
compliance behaviour
Item
hostility or refusal to cooperate.
boolean
C1321605 (UMLS CUI [1])
prosthetic devices pacemaker; mri
Item
any prosthetic devices (e.g., pacemaker or surgical clips) that could be affected by the magnetic field employed during mri imaging.
boolean
C0175649 (UMLS CUI [1,1])
C0030163 (UMLS CUI [1,2])
C0024485 (UMLS CUI [2])
cognitive impairment
Item
evidence of cognitive or memory impairment reaching early ad levels at the initial evaluation. at baseline, delayed paragraph recall z-scores > 2 below the reference group.
boolean
C1839000 (UMLS CUI [1])