Age
Item
aged 18 to 65 years-old.
boolean
C0001779 (UMLS CUI [1])
bmi
Item
18 ≤ bmi <30 kg/m².
boolean
C1305855 (UMLS CUI [1])
Asthma | Stable status
Item
clinical history consistent asthma, in the judgement of the investigator.
boolean
C0004096 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Persistent asthma, well controlled
Item
asthma controlled or partly controlled according to gina 2012 criteria:
boolean
C3661869 (UMLS CUI [1])
Therapeutic procedure | Asthma | inhaled steroids | Adrenergic beta-2 Receptor Agonists
Item
asthma treated by ics and laba (fixed-dose combination or free combination) at stable dose for at least 3 months.
boolean
C0087111 (UMLS CUI [1,1])
C0004096 (UMLS CUI [1,2])
C2065041 (UMLS CUI [2])
C2936789 (UMLS CUI [3])
Inhaled steroids | Salbutamol
Item
able to replace the usual ics and laba therapy by ics at the usual dose regimen and salbutamol as needed.
boolean
C2065041 (UMLS CUI [1])
C0001927 (UMLS CUI [2])
Ability | stop medication | salbutamol
Item
able to stop salbutamol at least 6 hours before a study visit.
boolean
C0085732 (UMLS CUI [1,1])
C0850893 (UMLS CUI [1,2])
C0001927 (UMLS CUI [1,3])
Ability | FEV1 | FVC
Item
able to perform at least 3 acceptable and reproducible fev1 and fvc measurements according to ers/ats 2005 recommendations.
boolean
C0085732 (UMLS CUI [1,1])
C0748133 (UMLS CUI [1,2])
C1287681 (UMLS CUI [2])
Respiration Disorders
Item
clinically significant respiratory conditions other than asthma (e.g. pneumonia, pneumothorax, atelectasis, bronchiectasis, chronic bronchitis, copd, emphysema, pulmonary arterial hypertension, pulmonary fibrosis,etc.).
boolean
C0035204 (UMLS CUI [1])
C0032285 (UMLS CUI [2])
C0032326 (UMLS CUI [3])
C0004144 (UMLS CUI [4])
C0006267 (UMLS CUI [5])
C0008677 (UMLS CUI [6])
C0024117 (UMLS CUI [7])
C0034067 (UMLS CUI [8])
C2973725 (UMLS CUI [9])
C0034069 (UMLS CUI [10])
Upper Respiratory Infections | Lower respiratory tract infection
Item
upper or lower respiratory tract infection within 4 weeks.
boolean
C0041912 (UMLS CUI [1])
C0149725 (UMLS CUI [2])
Exacerbation of asthma | Adrenal Cortex Hormones | Hospitalization
Item
exacerbation (requiring oral corticosteroids or hospitalization) within 3 months.
boolean
C0349790 (UMLS CUI [1])
C0001617 (UMLS CUI [2])
C0019993 (UMLS CUI [3])
Current smoker | Former smoker | smoking cigarettes: ____ pack-years history
Item
current smoker or former smoker less than 6 months or total lifetime smoking history greater than 10 pack-years.
boolean
C3241966 (UMLS CUI [1])
C0337671 (UMLS CUI [2])
C2230126 (UMLS CUI [3])
Intolerance | Salbutamol
Item
intolerance to salbutamol.
boolean
C1744706 (UMLS CUI [1,1])
C0001927 (UMLS CUI [1,2])
Intolerance | tiotropium | Atropine Derivatives
Item
intolerance to tiotropium (or any other atropine-derived compound).
boolean
C1744706 (UMLS CUI [1,1])
C0213771 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C0004260 (UMLS CUI [2,2])
Intolerance | Pharmaceutical Preparations | Clinical Research
Item
intolerance to one of the ingredients of the study product
boolean
C1744706 (UMLS CUI [1,1])
C1550600 (UMLS CUI [1,2])
C0013227 (UMLS CUI [1,3])
C0008972 (UMLS CUI [1,4])
Liver diseases | Moderate or Severe Renal Disease | Epilepsy | Angle Closure Glaucoma | Gastrointestinal obstruction | Prostatic Hypertrophy | Bladder neck obstruction
Item
severe hepatic impairment, moderate to severe renal impairment, epilepsy, narrow angle glaucoma, gastrointestinal obstruction, moderate to severe prostatic hypertrophy, bladder neck obstruction.
boolean
C0023895 (UMLS CUI [1])
C3829820 (UMLS CUI [2])
C0014544 (UMLS CUI [3])
C0017605 (UMLS CUI [4])
C0236124 (UMLS CUI [5])
C1739363 (UMLS CUI [6])
C0005694 (UMLS CUI [7])
Disease | Study Subject Participation Status
Item
any acute or chronic disease that will not allow the participation in the study, in the judgement of the investigator.
boolean
C0012634 (UMLS CUI [1])
C2348568 (UMLS CUI [2])
Physical Examination | Abnormality
Item
clinically relevant physical examination abnormality.
boolean
C0031809 (UMLS CUI [1,1])
C1704258 (UMLS CUI [1,2])