Informed consent
Item
written informed consent.
boolean
C0021430 (UMLS CUI [1])
Age | Gender
Item
male or female from 18 to 50 years of age.
boolean
C0001779 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
Asthma | Rhinitis | house dust mites | Allergic asthma | Allergic rhinitis
Item
diagnosed asthma and rhinitis with medical history consistent with hdm-induced allergic asthma and rhinitis.
boolean
C0004096 (UMLS CUI [1])
C0035455 (UMLS CUI [2])
C3539110 (UMLS CUI [3,1])
C0155877 (UMLS CUI [3,2])
C3539110 (UMLS CUI [4,1])
C2607914 (UMLS CUI [4,2])
Skin prick test | house dust mites | serum IgE measurement
Item
positive spt to hdm and and hdm-specific ige serum value ≥ 0.7 ku/l.
boolean
C0430561 (UMLS CUI [1,1])
C3539110 (UMLS CUI [1,2])
C2229760 (UMLS CUI [2])
Asthma therapy | Stable status
Item
stable asthma therapies.
boolean
C0087111 (UMLS CUI [1,1])
C0004096 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
FEV1 | Spirometry | pre bronchodilator
Item
spirometry (pre-bronchodilator) with best fev1 ≥ 70 percent of the predicted value.
boolean
C0748133 (UMLS CUI [1])
C0037981 (UMLS CUI [2,1])
C2599602 (UMLS CUI [2,2])
Spirometry reversibility | FEV1
Item
spirometry with reversibility in fev1 of ≥ 12 percent and ≥ 200 ml.
boolean
C1272658 (UMLS CUI [1])
C0748133 (UMLS CUI [2])
Asthma control test score
Item
asthma control test™ (act) score ≤ 19.
boolean
C2733224 (UMLS CUI [1])
Former smoker | pack-years history | Current Smoker
Item
former smoker with > 10 pack year history or current smoker.
boolean
C0337671 (UMLS CUI [1,1])
C2230126 (UMLS CUI [1,2])
C3241966 (UMLS CUI [2])
urine continine measurement
Item
patient with a urine level of cotinine ≥ 500 ng/ml.
boolean
C2188552 (UMLS CUI [1])
Sensitization | Allergens | Asthma | Symptoms
Item
co-sensitisation to any allergen possibly leading to clinically relevant symptoms likely to significantly change the asthma symptoms of the subject during the study.
boolean
C1325847 (UMLS CUI [1,1])
C0002092 (UMLS CUI [1,2])
C0392747 (UMLS CUI [2,1])
C0004096 (UMLS CUI [2,2])
C1457887 (UMLS CUI [2,3])
Allergen Immunotherapy | house dust mites
Item
patient who received allergen immunotherapy for hdm within the past 10 years.
boolean
C0162352 (UMLS CUI [1,1])
C3539110 (UMLS CUI [1,2])
Immunotherapy | Aeroallergen
Item
ongoing immunotherapy for an aeroallergen other than house dust mite.
boolean
C0021083 (UMLS CUI [1,1])
C0001697 (UMLS CUI [1,2])
C3539110 (UMLS CUI [2])
condition of oral cavity | Study Subject Participation Status
Item
patient with any oral condition that could confound the safety assessments or planning to have a dental extraction during the study.
boolean
C2010703 (UMLS CUI [1])
C2348568 (UMLS CUI [2])
C0549076 (UMLS CUI [3])
C0040440 (UMLS CUI [4])
Therapeutic procedure | Adrenergic beta-1 Receptor Antagonists | Tricyclic Antidepressive Agents | Monoamine Oxidase Inhibitors
Item
patient treated with beta-blockers, tricyclic antidepressants or monoamine oxidase inhibitors (maois).
boolean
C0087111 (UMLS CUI [1,1])
C0304516 (UMLS CUI [1,2])
C0003290 (UMLS CUI [2])
C0026457 (UMLS CUI [3])
Pregnancy | Breast Feeding
Item
pregnant women or breast-feeding/lactating.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Woman | Childbearing Potential | Contraceptive methods
Item
women with childbearing potential who are not using a medically accepted birth control method.
boolean
C0043210 (UMLS CUI [1,1])
C3831118 (UMLS CUI [1,2])
C0700589 (UMLS CUI [2])
Disease | Study Subject Participation Status
Item
patient with a past or current disease, which as judged by the investigator, may affect the patient's participation in, or the outcome of this study.
boolean
C0012634 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])