Age
Item
be at least 6 years of age and younger than 15 years of age
boolean
C0001779 (UMLS CUI [1])
Asthma
Item
have physician-diagnosed asthma
boolean
C0004096 (UMLS CUI [1])
Asthma | inhaled steroids | fluticasone
Item
taking a medium dose of ics (e.g. fluticasone 220mcg bid) for daily asthma control for at least 6 months in the prior year.
boolean
C0004096 (UMLS CUI [1])
C2065041 (UMLS CUI [2])
C0082607 (UMLS CUI [3])
Exacerbation of severe persistent asthma | Intramuscular steroid therapy | Intravenous steroid injection | Adrenal Cortex Hormones
Item
have had a severe asthma exacerbation in the previous year, defined as an emergency department (ed) visit, hospitalization, or unscheduled clinic visit for asthma resulting in intramuscular, intravenous, or oral steroids.
boolean
C3508930 (UMLS CUI [1])
C0586082 (UMLS CUI [2])
C0019993 (UMLS CUI [3])
C0585373 (UMLS CUI [4])
C0563322 (UMLS CUI [5])
C0001617 (UMLS CUI [6])
response to bronchodilator | FEV1 | Inhaled albuterol | Respiratory Hypersensitivity
Item
have bronchodilator responsiveness (bdr, an increase in fev1 ≥12 percent from baseline after administration of inhaled albuterol) or (if no bdr) increased airway responsiveness to methacholine challenge
boolean
C3548479 (UMLS CUI [1])
C0748133 (UMLS CUI [2])
C0354688 (UMLS CUI [3])
C0035228 (UMLS CUI [4,1])
C0430567 (UMLS CUI [4,2])
Vitamin d insufficiency | Serum vitamin D measurement
Item
have vitamin d insufficiency (a serum vitamin d (25(oh)d) level <30 ng/ml)
boolean
C0231179 (UMLS CUI [1,1])
C0042866 (UMLS CUI [1,2])
C0428586 (UMLS CUI [2])
Informed consent
Item
have his/her parents give voluntary written consent to participate in the study
boolean
C0021430 (UMLS CUI [1])
Respiration Disorders | Bronchiectasis
Item
chronic respiratory disorder other than asthma (e.g., bronchiectasis).
boolean
C0035204 (UMLS CUI [1])
C0006267 (UMLS CUI [2])
C0004096 (UMLS CUI [3])
Severe asthma | medication for chronic disease | Intubation | Hospitalization | Exacerbation of severe persistent asthma
Item
severe asthma, as evidenced by any of the following: a) chronic need for medication other than single controller therapy and inhaled β2-agonist, b) intubation for asthma at any time, and c) ≥2 hospitalizations or ≥6 severe asthma exacerbations in the previous year
boolean
C0581126 (UMLS CUI [1])
C3495005 (UMLS CUI [2])
C0021925 (UMLS CUI [3])
C0019993 (UMLS CUI [4])
C3508930 (UMLS CUI [5])
cigarette smoking | pack-years history
Item
history of cigarette smoking in the prior year or former smoking if ≥5 pack-years
boolean
C0543414 (UMLS CUI [1])
C2230126 (UMLS CUI [2])
Liver diseases | Kidney Diseases | Rickets | Malabsorption | Chronic disease
Item
hepatic or renal disease, metabolic rickets, malabsorptive disorders, or other chronic diseases that would affect vitamin d metabolism
boolean
C0023895 (UMLS CUI [1])
C0022658 (UMLS CUI [2])
C0035579 (UMLS CUI [3])
C3714745 (UMLS CUI [4])
C0008679 (UMLS CUI [5,1])
C0392760 (UMLS CUI [5,2])
C1159433 (UMLS CUI [5,3])
Immune deficiency | Cleft Palate | Down Syndrome
Item
immune deficiency, cleft palate or down's syndrome, which might increase the child's likelihood of respiratory infections
boolean
C1855771 (UMLS CUI [1])
C0008925 (UMLS CUI [2])
C0013080 (UMLS CUI [3])
Therapeutic procedure | Anticonvulsants | Vitamin D
Item
treatment with anticonvulsants or pharmacological doses of vitamin d (≥1,000 iu/day of vitamin d2 or d3)
boolean
C0087111 (UMLS CUI [1,1])
C0003286 (UMLS CUI [1,2])
C0042866 (UMLS CUI [2,1])
C0013058 (UMLS CUI [2,2])
Therapeutic procedure | Oral steroids
Item
chronic oral corticosteroid therapy
boolean
C0087111 (UMLS CUI [1,1])
C0001617 (UMLS CUI [1,2])
Unable | Spirometry
Item
inability to perform acceptable spirometry
boolean
C1299582 (UMLS CUI [1,1])
C0037981 (UMLS CUI [1,2])
Therapies, Investigational | Study Subject Participation Status
Item
use of investigational therapies or participation in clinical trials 30 days before or during the duration of the study
boolean
C0949266 (UMLS CUI [1])
C2348568 (UMLS CUI [2])
serum calcium
Item
serum calcium >10.8 mg/dl
boolean
C0728876 (UMLS CUI [1])
Severe vitamin d deficiency
Item
serum 25(oh) d <10 ng/ml (severe vitamin d deficiency)
boolean
C0042870 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])