dsm-iv; major depressive disorder
Item
dsm-iv diagnosis of single or recurrent, non-psychotic, major depressive disorder
boolean
C0220952 (UMLS CUI [1])
C1269683 (UMLS CUI [2])
selective serotonin reuptake inhibitor; serotonin-norepinephrine reuptake inhibitor; mirtazapine
Item
currently taking a selective serotonin reuptake inhibitor (ssri) or serotonin-norepinephrine reuptake inhibitor (snri) or mirtazapine for major depressive disorder
boolean
C0360105 (UMLS CUI [1])
C3537213 (UMLS CUI [2])
C0049506 (UMLS CUI [3])
antidepressant; therapy major depressive episode
Item
need for "next-step" treatment based on documented suboptimal outcome from current antidepressant treatment for major depressive episode (at least 6 weeks treatment with a qids-c16 >= 16 or at least 8 weeks with a qids-c16 >= 11; and at least 3 weeks at a stable "optimal" dose
boolean
C0003289 (UMLS CUI [1])
C0087111 (UMLS CUI [2,1])
C0154409 (UMLS CUI [2,2])
age
Item
age: 18 years of age or older
boolean
C0001779 (UMLS CUI [1])
hypersensitivity study drugs
Item
prior inadequate response after an adequate treatment trial or clear cut intolerance to either of the study medications (aripiprazole or bupropion)
boolean
C0020517 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C0008972 (UMLS CUI [1,3])
antipsychotic agent bupropion aripiprazole
Item
current treatment with bupropion, aripiprazole or any other antipsychotic agent
boolean
C0040615 (UMLS CUI [1,1])
C0085208 (UMLS CUI [1,2])
C0299792 (UMLS CUI [1,3])
bipolar disorder; schizophrenia; psychosis
Item
lifetime history of bipolar disorder, schizophrenia, schizoaffective disorder, or psychosis not otherwise specified
boolean
C0005586 (UMLS CUI [1])
C0036341 (UMLS CUI [2])
C0033975 (UMLS CUI [3])
dementia
Item
current diagnosis of dementia
boolean
C0497327 (UMLS CUI [1])
eating disorder; seizure disorder
Item
current diagnosis of an eating disorder or a seizure disorder
boolean
C0013473 (UMLS CUI [1])
C0014544 (UMLS CUI [2])
High suicide risk
Item
high suicide risk currently requiring acute intervention (other than outpatient treatment of depression)
boolean
C1271074 (UMLS CUI [1])
comorbidity; hospitalization
Item
unstable, serious medical condition or one requiring acute medical treatment, or anticipation of hospitalization for extended care
boolean
C0009488 (UMLS CUI [1])
C0019993 (UMLS CUI [2])
hospitalization psychiatric disorders
Item
requiring immediate hospitalization for psychiatric disorders
boolean
C0019993 (UMLS CUI [1,1])
C0004936 (UMLS CUI [1,2])
drug detoxification; Substance Use Disorder
Item
physiologic substance dependence requiring detoxification (excluding nicotine) in the past 30 days (substance abuse is not an exclusion criteria)
boolean
C0025516 (UMLS CUI [1])
C0038586 (UMLS CUI [2])
concomitant medication
Item
taking any concomitant medication that contraindicates any of treatment options or augmenting agents known to have an antidepressant effect
boolean
C2347852 (UMLS CUI [1])
Study Subject Participation Status
Item
concurrent or recent participation (within the last 30 days) in another conflicting clinical trial with a mental health, investigational drug, or medical device intervention
boolean
C2348568 (UMLS CUI [1])
pregnancy; lactating
Item
female - pregnant or lactating or planning to become pregnant
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
informed consent
Item
patient was not able or willing to provide informed consent; or changed mind about participating prior to randomization
boolean
C0021430 (UMLS CUI [1])
Clinical Research
Item
patient was not referred to the study
boolean
C0008972 (UMLS CUI [1])