AML
Item
acute myeloid leukemia (aml), any subtype including acute promyelocytic leukemia (apl). patients with either de novo or secondary aml are eligible.
boolean
C0023467 (UMLS CUI [1])
prior aml induction chemotherapy
Item
no prior aml induction chemotherapy.
boolean
C1514463 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
ID.3
Item
due to receive standard 3+7 induction chemotherapy using daunorubicin on days 1-3, plus cytarabine continuous infusion daily on days 1-7.
boolean
age
Item
age 18 and over.
boolean
C0001779 (UMLS CUI [1])
bilirubin
Item
serum bilirubin < or = 1.5 times the upper limit of normal (uln).
boolean
C1278039 (UMLS CUI [1])
AST and ALT
Item
serum aspartate aminotransferase and alanine aminotransferase < or = 2.5 times the uln.
boolean
C0201836 (UMLS CUI [1,1])
C0201899 (UMLS CUI [1,2])
creatinine
Item
serum creatinine < 200 umol/l
boolean
C0201976 (UMLS CUI [1])
nausea or vomiting
Item
uncontrolled nausea or vomiting within 48 hours prior to start of induction therapy. grade 0-1 nausea is permitted at the start of induction.
boolean
C0027497 (UMLS CUI [1])
C0042963 (UMLS CUI [2])
hypersensitivity to granisetron or aprepitant
Item
known hypersensitivity to granisetron or aprepitant.
boolean
C0020517 (UMLS CUI [1,1])
C0061863 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C1176306 (UMLS CUI [2,2])
CYP3A4 inhibitors
Item
patients currently receiving treatment with strong cyp3a4 inhibitors or substrates and treatment cannot be either discontinued or switched to a different medication prior to starting study drug.
boolean
C3830624 (UMLS CUI [1])
not able to swallow or absorb oral medications
Item
not able to swallow or absorb oral medications.
boolean
C0175795 (UMLS CUI [1])
cns leukemia or recent cns hemorrhage
Item
documented active central nervous system (cns) leukemia or recent cns hemorrhage.
boolean
C1332884 (UMLS CUI [1])
C1560581 (UMLS CUI [2])
investigational therapy
Item
1. other investigational agents during induction therapy
boolean
C0949266 (UMLS CUI [1,1])
C0205420 (UMLS CUI [1,2])
radiotherapy
Item
2. radiotherapy during, or one month prior to, induction therapy
boolean
C1522449 (UMLS CUI [1,1])
C0040223 (UMLS CUI [1,2])
systemic corticosteroids
Item
3. systemic corticosteroids
boolean
C2825233 (UMLS CUI [1])
other chemotherapy
Item
4. other chemotherapy agents on days 1-8
boolean
C0003392 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
pregnancy or lactation
Item
pregnant or breast feeding.
boolean
C0032961 (UMLS CUI [1,1])
C0006147 (UMLS CUI [1,2])