idiopathic parkinson disease
Item
diagnosis of idiopathic pd according to the united kingdom parkinson's disease society brain bank criteria (ukpdsbb) criteria (only for pd group
boolean
C0865475 (UMLS CUI [1])
age
Item
age 50 to 75 years
boolean
C0001779 (UMLS CUI [1])
informed consent
Item
able to give informed consent for study participation
boolean
C0021430 (UMLS CUI [1])
medication Parkinson Disease; Anticholinergic Agents
Item
not on any medication for pd (anticholinergic agents allowed)
boolean
C0013227 (UMLS CUI [1,1])
C0030567 (UMLS CUI [1,2])
C0242896 (UMLS CUI [2])
informed consent
Item
unable to give informed consent
boolean
C0021430 (UMLS CUI [1])
brain mri
Item
unable to undergo a brain mri
boolean
C0412675 (UMLS CUI [1])
disease duration Parkinson Disease
Item
pd duration ≥15 years
boolean
C0872146 (UMLS CUI [1,1])
C0030567 (UMLS CUI [1,2])
neuroleptics; prochlorperazine; metoclopramide
Item
receiving dopamine receptor blocking agents, including typical neuroleptics, prochlorperazine, and metoclopramide
boolean
C0040615 (UMLS CUI [1])
C0033229 (UMLS CUI [2])
C0025853 (UMLS CUI [3])
major depression
Item
diagnosis of major depression or other axis i psychopathology
boolean
C1269683 (UMLS CUI [1])
Mini-mental state examination
Item
modified mini-mental status exam (mmse) ≤ 24/30
boolean
C0451306 (UMLS CUI [1])
diabetes; congestive heart failure
Item
diagnosis of chronic or persistent illnesses that could affect oxidative stress status, such as diabetes or congestive heart failure
boolean
C0011847 (UMLS CUI [1])
C0018802 (UMLS CUI [2])
life expectancy limited comorbidity
Item
significant concomitant medical disease limiting life expectancy to less than 12 months from study inclusion
boolean
C0023671 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
Mitochondrial Diseases; epilepsy; stroke; multiple sclerosis; Alzheimers Disease
Item
diagnosis of primary mitochondrial disorder, epilepsy, stroke, multiple sclerosis or other neurodegenerative diseases such as alzheimer's disease or als
boolean
C0751651 (UMLS CUI [1])
C0014544 (UMLS CUI [2])
C0038454 (UMLS CUI [3])
C0026769 (UMLS CUI [4])
C0002395 (UMLS CUI [5])