idiopathic parkinson, responsive do levodopa
Item
idiopathic parkinson's disease of at least 7 years duration and responsive to levodopa. other parkinson syndromes excluded.
boolean
C0747270 (UMLS CUI [1])
C0023570 (UMLS CUI [2,1])
C0521982 (UMLS CUI [2,2])
prior therapy
Item
patients previously tried on other available forms of medical treatment.
boolean
C1514463 (UMLS CUI [1])
age
Item
age between 20 and 75 years.
boolean
C0001779 (UMLS CUI [1])
intractable problems
Item
presence of an intractable problem, such as "off" periods, dyskinesias, or "freezing," not controlled by dopamine agonists such as levodopa or pergolide.
boolean
C0009566 (UMLS CUI [1])
C0009488 (UMLS CUI [2])
depression, cognitive impairment
Item
no serious depression and no cognitive impairment.
boolean
C0011581 (UMLS CUI [1])
C0009241 (UMLS CUI [2])
completion of home diary
Item
successful completion of home diary by patient or responsible party.
boolean
C1321605 (UMLS CUI [1])
videotape recordings of on and off status
Item
successful videotape recordings at home of "on" and "off" status.
boolean
C1321605 (UMLS CUI [1])
mri of brain
Item
normal mri of brain within the last 18 months.
boolean
C0412675 (UMLS CUI [1])
fluorodopa pet scan
Item
fluorodopa pet scan compatible with idiopathic parkinson's disease.
boolean
C0412496 (UMLS CUI [1])
C3652462 (UMLS CUI [2])
fit to undergo implant surgery
Item
medically fit to undergo implant surgery with certification by the patient's physician.
boolean
C1321605 (UMLS CUI [1])
C0038894 (UMLS CUI [2])
able to financially cover expenses
Item
able to financially cover expenses not paid for by nih grant (between $1,000 and
boolean
C1321605 (UMLS CUI [1])
$2,000 costs
Item
$2,000 for unreimbursed travel, video camera, and blood screening as specified in the consent form.
boolean
C1321605 (UMLS CUI [1])
severe or moderately severe depression or cognitive impairment
Item
severe or moderately severe depression or cognitive impairment.
boolean
C0011581 (UMLS CUI [1])
C0009241 (UMLS CUI [2])
brain surgery
Item
previous brain surgery.
boolean
C0195775 (UMLS CUI [1])
Comorbidities
Item
presence of diabetes mellitus, severe cardiopulmonary disease or other severe medical disease, or mri evidence of cerebrovascular disease.
boolean
C0009488 (UMLS CUI [1])
not ready to undergo a surgical procedure, informed consent
Item
not medically cleared to undergo a surgical procedure.
boolean
C0021430 (UMLS CUI [1])