hematological or lymphatic malignancy
Item
Histopathologically-confirmed diagnosis of hematological or lymphatic malignancy, defined as one of the following:
boolean
C0376545 (UMLS CUI [1])
C0006826 (UMLS CUI [2,1])
C1522604 (UMLS CUI [2,2])
AML as primary ref disease or in relapse
Item
Acute myeloid leukemia (aml) as primary refractory disease, or in relapse
boolean
C0023467 (UMLS CUI [1,1])
C1514815 (UMLS CUI [1,2])
C0023467 (UMLS CUI [2,1])
C0277556 (UMLS CUI [2,2])
AML first remission
Item
acute leukemia in first remission with poor risk factors and molecular prognosis
boolean
C0153886 (UMLS CUI [1,1])
C0205435 (UMLS CUI [1,2])
chromosome abnormalities
Item
aml with -5,-7, t(6;9), tri8, -11
boolean
C4015468 (UMLS CUI [1])
ALL type
Item
acute lymphocytic / lymphoblastic leukemia (all) with phil+ t(9;22),(q34;q11.2), and t(4:11)(q21;23)
boolean
C0023449 (UMLS CUI [1,1])
C1709527 (UMLS CUI [1,2])
C0023449 (UMLS CUI [2,1])
C3688703 (UMLS CUI [2,2])
CML
Item
Chronic myelogenous leukemia (cml in accelerated, second chronic phase)
boolean
C0023474 (UMLS CUI [1,1])
C0521110 (UMLS CUI [1,2])
myelodysplastic syndrome
Item
Myelodysplastic syndrome with high intermediate to high risk categories
boolean
C3463824 (UMLS CUI [1])
NHL
Item
Non-hodgkin's lymphoma (nhl)
boolean
C0024305 (UMLS CUI [1])
CLL
Item
Chronic lymphocytic leukemia (cll), refractory
boolean
C0023434 (UMLS CUI [1,1])
C0205269 (UMLS CUI [1,2])
creatinine clearance bilirubin and alt measurement
Item
Creatinine clearance > 50 ml/min for those above serum creatinine of 1.5 mg/dl, serum bilirubin < 2.0 mg/dl, alt < 2x uln (unless secondary to disease)
boolean
C0373595 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
age diagnosis CLL
Item
< 50 years old at time of registration
boolean
C1828181 (UMLS CUI [1])
donor criteria
Item
Donor is related, Donor is genotypically-matched and haploidentical for HLA-A, B,C and DRB1, DQ loci Donor differs for 2 or 3 HLA alleles on the unshared haplotype in the GvHD direction
boolean
C3494891 (UMLS CUI [1])
C1285573 (UMLS CUI [2])
C3829897 (UMLS CUI [3,1])
C0019721 (UMLS CUI [3,2])
C3829897 (UMLS CUI [4,1])
C0122040 (UMLS CUI [4,2])
C0972850 (UMLS CUI [5])
no HLA match identified
Item
No HLA-matched sibling or matched unrelated donor is identified
boolean
C0019721 (UMLS CUI [1,1])
C3242262 (UMLS CUI [1,2])
ECOG performance status
Item
ECOG performance status not more than 2
boolean
C1520224 (UMLS CUI [1])
LVEF
Item
LVEF
boolean
C0428772 (UMLS CUI [1])
DLCO
Item
DLCO > 50%
boolean
C1516251 (UMLS CUI [1])
serum creatinine
Item
Corrected for hemoglobin Serum creatinine < 1.5 mg/dL
boolean
C0201976 (UMLS CUI [1])
pregnancy test beta-HCG
Item
Females of childbearing potential must have a negative serum or urine beta-HCG test within 3 weeks of registration
boolean
C0032961 (UMLS CUI [1])
C0106132 (UMLS CUI [2])
no prior cancer
Item
No prior cancer within 5 years with the exception of surgically-cured, non-melanoma skin cancer or in situ cancer of the cervix
text
C0006826 (UMLS CUI [1])
myeloablative therapy or transplant
Item
No prior myeloablative therapy or transplant
boolean
C1513784 (UMLS CUI [1])
C0005961 (UMLS CUI [2])
informed consent
Item
Duly-executed informed consent
boolean
C0021430 (UMLS CUI [1])
autologous transplantation
Item
Suitable candidate for autologous transplantation
boolean
C0040736 (UMLS CUI [1,1])
C1548635 (UMLS CUI [1,2])
participation in another study
Item
Participation in other investigational drugs or devices trials that might influence the study endpoints
boolean
C2348568 (UMLS CUI [1])
active hepatitis
Item
Evidence of active hepatitis
boolean
C0019158 (UMLS CUI [1,1])
C0205177 (UMLS CUI [1,2])
active cirrhosis
Item
Evidence of active cirrhosis
boolean
C1623038 (UMLS CUI [1,1])
C0205177 (UMLS CUI [1,2])
HIV positive
Item
HIV-positive
boolean
C0019699 (UMLS CUI [1])
invasive aspergillosis
Item
History of invasive aspergillosis
boolean
C0238013 (UMLS CUI [1])
uncontrolled active infection
Item
Presence of any other uncontrolled, active infection, ie, bacterial, viral or fungal
boolean
C0009450 (UMLS CUI [1])
uncontrolled CNS involvement
Item
Uncontrolled CNS involvement
boolean
C0449389 (UMLS CUI [1])
allergy to murine proteins
Item
Documented allergy to murine proteins
boolean
C0020517 (UMLS CUI [1,1])
C1699668 (UMLS CUI [1,2])
allergy to iron dextran
Item
Documented allergy to iron dextran
boolean
C0020517 (UMLS CUI [1,1])
C0022092 (UMLS CUI [1,2])
contraceptive use
Item
Female of child-bearing potential unwilling to implement adequate birth control
boolean
C1999124 (UMLS CUI [1])
comorbidities affecting compliance and transplantation
Item
Medical problem / neurologic/psychiatric dysfunction which would impair his/her ability to be compliant with the medical regimen and/or to tolerate transplantation, in the opinion of the principal investigator
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0005961 (UMLS CUI [2,3])
comorbidities prolonging hematologic recovery
Item
Medical problem / neurologic/psychiatric dysfunction which would prolong hematologic recovery and place the recipient at unacceptable risk, in the opinion of the principal investigator would
boolean
C0009488 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0237820 (UMLS CUI [1,3])
age
Item
Age < 60 years
boolean
C0001779 (UMLS CUI [1])
weight
Item
Weight > 25 kg
boolean
C0005910 (UMLS CUI [1])
good health status
Item
Medical history and physical examination confirm good health status as defined by institutional standards
boolean
C0018759 (UMLS CUI [1,1])
C0205170 (UMLS CUI [1,2])
HIV negative
Item
Within 30 days of apheresis collection, seronegative for HIV assessed as HIV Ag; HIV 1+2 Ab; or HTLV I/II Ab
boolean
C0481430 (UMLS CUI [1])
seronegative for hepatitis
Item
Within 30 days of apheresis collection, seronegative for hepatitis assessed as HBsAg; HBcAb (IgM and IgG); or HCV Ab
boolean
C0019158 (UMLS CUI [1,1])
C0521144 (UMLS CUI [1,2])
seronegative for syphilis
Item
Within 30 days of apheresis collection, seronegative for syphilis assessed as RPR
boolean
C0039128 (UMLS CUI [1,1])
C0521144 (UMLS CUI [1,2])
HLA haploidentical
Item
Genotypically haploidentical as determined by HLA typing
boolean
C0242318 (UMLS CUI [1,1])
C3829897 (UMLS CUI [1,2])
pregnancy test donor
Item
Female donors of child-bearing potential must have a negative serum or urine beta-HCG test within 3 weeks of mobilization
boolean
C0032961 (UMLS CUI [1])
C0106132 (UMLS CUI [2])
capable leukapheresis
Item
Capable of undergoing leukapheresis, Has adequate venous access
boolean
C0023416 (UMLS CUI [1,1])
C1548635 (UMLS CUI [1,2])
C0750164 (UMLS CUI [2,1])
C1548635 (UMLS CUI [2,2])
consent to central catheter
Item
Willing to undergo insertion of a central catheter should leukapheresis via peripheral vein be inadequate
boolean
C2322576 (UMLS CUI [1,1])
C1511481 (UMLS CUI [1,2])
consent to second donation
Item
Agreeable to second donation of PBPC (or a bone marrow harvest) should the recipient fail to demonstrate sustained engraftment following the transplant
boolean
C0242602 (UMLS CUI [1,1])
C1517331 (UMLS CUI [1,2])
C1511481 (UMLS CUI [1,3])
informed consent donor
Item
Duly-executed informed consent
boolean
C0021430 (UMLS CUI [1])
CMV seroreactivity
Item
Screened for CMV seroreactivity
boolean
C0010823 (UMLS CUI [1,1])
C0521143 (UMLS CUI [1,2])
active infection
Item
Evidence of active infection (including urinary tract infection, or upper respiratory tract infection)
boolean
C0009450 (UMLS CUI [1])
C0042029 (UMLS CUI [2])
C0041912 (UMLS CUI [3])
hepatitis donor
Item
Evidence of hepatitis (on screening)
boolean
C0019158 (UMLS CUI [1])
contraindications to growth factor therapy and leukapheresis
Item
Medical, physical or psychological reason which makes the donor unlikely to tolerate or cooperate with growth factor therapy and leukapheresis
boolean
C0009488 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0280112 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0023416 (UMLS CUI [2,3])
increased risk for leukapheresis or G-CSF-related complications
Item
Factors placing donor at increased risk for leukapheresis or G-CSF-related complications
boolean
C0035648 (UMLS CUI [1,1])
C0023416 (UMLS CUI [1,2])
C0035648 (UMLS CUI [2,1])
C0079459 (UMLS CUI [2,2])
lactation and contraceptive use
Item
Lactating female, Female of child-bearing potential unwilling to implement adequate birth control
boolean
C2828358 (UMLS CUI [1])
C1999124 (UMLS CUI [2])
HIV positive donor
Item
HIV-positive
boolean
C0019699 (UMLS CUI [1])