Age
Item
19-60 years of age
boolean
C0001779 (UMLS CUI [1])
schizophrenia
Item
diagnosis of schizophrenia
boolean
C0036341 (UMLS CUI [1])
bprs score
Item
bprs score > 50
boolean
C0029941 (UMLS CUI [1])
clinical global impression
Item
clinical global impressions rating > 4
boolean
C3639708 (UMLS CUI [1])
bprs items, conceptual disorganization, suspiciousness, hallucinations, unusual thought content
Item
one of the following: bprs items rated greater than or equal to 4, conceptual disorganization, suspiciousness, hallucinations, unusual thought content.
boolean
C0029941 (UMLS CUI [1])
neuroleptics
Item
at least 2 six-week trials of different neuroleptics given at a dosage equivalent to at least 600 mg per day of chlorpromazine or at least 1 eight-week trial of a neuroleptic given at a dosage equivalent to at least 800 mg per day of chlorpromazine.
boolean
C0040615 (UMLS CUI [1])
C0008286 (UMLS CUI [2])
informed consent
Item
the patient (or the patient's authorized legal representative) must understand the nature of the study and sign the informed consent.
boolean
C0021430 (UMLS CUI [1])
substance dependence
Item
history of substance dependence within the past 2 months
boolean
C0038586 (UMLS CUI [1])
contraindications clozapine
Item
major medical problems precluding the use of clozapine
boolean
C0009488 (UMLS CUI [1])
C1301624 (UMLS CUI [2,1])
C0009079 (UMLS CUI [2,2])
pregnancy or lactation
Item
pregnancy or lactation
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
suicidal, homicide risk
Item
a serious suicide/homicide risk
boolean
C0438696 (UMLS CUI [1])
C0019872 (UMLS CUI [2])