mantle cell lymphoma
Item
tissue diagnosis of mantle cell lymphoma (confirmed in laboratory of pathology). blastic cell variant will be eligible.
boolean
C0030664 (UMLS CUI [1,1])
C0334634 (UMLS CUI [1,2])
age
Item
age greater than or equal to 18.
boolean
C0001779 (UMLS CUI [1])
chemotherapy
Item
previously untreated with cytotoxic chemotherapy. patients may have received local radiation or a short course of steroids for control of symptoms.
boolean
C0392920 (UMLS CUI [1])
disease stage
Item
all stages of disease.
boolean
C0699749 (UMLS CUI [1])
lymph nodes, circulating tumor cells
Item
lymph node of greater than or equal to 2 cm accessible for biopsy/harvest or greater than 1000/microliters of circulating tumor cells in the blood.
boolean
C0024204 (UMLS CUI [1])
C3272887 (UMLS CUI [2])
ecog
Item
ecog performance status of less than or equal to 3.
boolean
C1520224 (UMLS CUI [1])
organ function
Item
adequate major organ function (serum creatinine 1.5 mg/dl or creatinine clearance greater than 60 ml/min; bilirubin less than 2 mg/dl (total) except less than 5 mg/dl in patients with gilbert's syndrome as defined by greater than 80% unconjugated; anc greater than 1000 and platelets greater than 100,000) unless impairment due to organ involvement by lymphoma.
boolean
C0201976 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
C1278039 (UMLS CUI [3])
C0948762 (UMLS CUI [4])
C0032181 (UMLS CUI [5])
cardiac disease
Item
no active symptomatic ischemic heart disease, myocardial infarction or congestive heart failure within the past year. if muga is obtained, the lvef should exceed 40%.
boolean
C0018799 (UMLS CUI [1])
informed consent
Item
ability to give informed consent.
boolean
C0021430 (UMLS CUI [1])
hiv, hepatitis b
Item
antibodies to hiv or presence of hepatitis b surface antigen.
boolean
C0019683 (UMLS CUI [1])
C0019168 (UMLS CUI [2])
pregnant or lactating
Item
pregnant or lactating.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
malignancy
Item
prior malignancy in past 5 years except squamous or basal cell carcinoma or curatively treated in situ of the cervix.
boolean
C0006826 (UMLS CUI [1])
cns involvement
Item
involvement of central nervous system by lymphoma.
boolean
C0449389 (UMLS CUI [1])