AML or MDS
Item
patients with a diagnosis of aml or high-risk mds (based on international prognostic scoring system (ipss): refractory anemia with excess of blasts (raeb) or raeb in transformation [raeb-t]) receiving frontline induction chemotherapy with any high dose or conventional dose cytarabine-containing regimen or clofarabine-containing regimen at md anderson cancer center.
boolean
C0023467 (UMLS CUI [1])
C3463824 (UMLS CUI [2])
induction chemotherapy
Item
patients must be enrolled on the study within two weeks of the start of induction chemotherapy.
boolean
C0392920 (UMLS CUI [1])
iron, vitamin b12, or folate deficiency
Item
patients with documented iron, vitamin b12, or folate deficiency are eligible, but should receive replacement therapy while on study.
boolean
C0302583 (UMLS CUI [1])
C0202252 (UMLS CUI [2])
C0523631 (UMLS CUI [3])
informed consent
Item
understand and voluntarily sign an informed consent form.
boolean
C0021430 (UMLS CUI [1])
erythropoietin
Item
patients with prior treatment with any form of erythropoietin within the previous month.
boolean
C0014822 (UMLS CUI [1])
hypertension (> or =140/90), uncontrolled, clinically significant cardiac arrhythmias, or history of pulmonary embolism or thrombosis
Item
patients with uncontrolled hypertension (> or =140/90), uncontrolled, clinically significant cardiac arrhythmias, or history of pulmonary embolism or thrombosis within the last 5 years.
boolean
C0020538 (UMLS CUI [1])
C0003811 (UMLS CUI [2])
C0034065 (UMLS CUI [3])
C0040053 (UMLS CUI [4])
seizures
Item
new onset (within 3 months prior to randomization) or poorly controlled seizures.
boolean
C0036572 (UMLS CUI [1])
hypersensitivity to the active substance
Item
patients with known hypersensitivity to the active substance or any of the excipients.
boolean
C0020517 (UMLS CUI [1,1])
C0733467 (UMLS CUI [1,2])
pregnancy or lactation
Item
pregnant or lactating women.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
erythroleukemia
Item
acute erythroleukemia (m6 french-american-british (fab) classification)
boolean
C0023440 (UMLS CUI [1])
hemoglobin
Item
hemoglobin greater than or equal to 10g/dl
boolean
C0019046 (UMLS CUI [1])
head and neck cancer
Item
patients with head and neck cancer receiving radiation therapy when erythropoiesis-stimulating agents (esas) were given to maintain hemoglobin levels of more than 12 g/dl.
boolean
C0278996 (UMLS CUI [1])
metastatic breast cancer
Item
patients with metastatic breast cancer receiving chemotherapy when esas were given to maintain hemoglobin levels of more than 12 g/dl.
boolean
C0678222 (UMLS CUI [1])
kidney failure
Item
patients with chronic kidney failure when esas were given to maintain hemoglobin levels of more than 12 g/dl.
boolean
C0035078 (UMLS CUI [1])
major surgery
Item
patients requiring major surgery would be taken off study due to a higher chance of blood clots being reported while taking esas.
boolean
C0543467 (UMLS CUI [1])