AML diagnosis
Item
a diagnosis of acute myeloid leukemia (aml), either m4 or m5 subtype de novo or resulting from a transformation from mds or a myeloproliferative disorder.
boolean
C0023467 (UMLS CUI [1])
patients with aml who (a) have failed primary therapy -defined as failing two induction chemotherapies, (b) have relapsed or (c) are not suitable for intensive induction chemotherapy will be eligible. or
Item
patients with aml who (a) have failed primary therapy -defined as failing two induction chemotherapies, (b) have relapsed or (c) are not suitable for intensive induction chemotherapy will be eligible. or
boolean
C0023467 (UMLS CUI [1])
AML blast crisis from CML
Item
patients with aml blast crisis from cml if they are not suitable candidates for intensive induction chemotherapy or have failed imatinib mesylate or
boolean
C0023474 (UMLS CUI [1])
secondary aml after mds
Item
patients with secondary aml after mds if they are not suitable candidates for intensive induction chemotherapy.
boolean
C3463824 (UMLS CUI [1])
ECOG performance status
Item
ecog 0,1,2, or 3
boolean
C1520224 (UMLS CUI [1])
life expectancy
Item
life expectancy > 12 weeks.
boolean
C0023671 (UMLS CUI [1])
renal and hepatic function
Item
adequate renal and hepatic function
boolean
C0232804 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
uncontrolled central nervous system involvement by aml
Item
uncontrolled central nervous system involvement by aml
boolean
C3714787 (UMLS CUI [1])
NYHA
Item
active cardiovascular disease as defined by nyha class iii-iv categorization.
boolean
C1275491 (UMLS CUI [1])
intercurrent illness or medical condition precluding safe administration of ribavirin
Item
intercurrent illness or medical condition precluding safe administration of ribavirin.
boolean
C0035525 (UMLS CUI [1])
received any previous therapy within 28 days prior to study entry.hydrea is permitted but must be stopped 7 days prior to starting study drug
Item
received any previous therapy within 28 days prior to study entry.hydrea is permitted but must be stopped 7 days prior to starting study drug.
boolean
C0020402 (UMLS CUI [1])
HIV
Item
known infection with hiv.
boolean
C0019682 (UMLS CUI [1])