age
Item
aged 80 or older
boolean
C0001779 (UMLS CUI [1])
bp
Item
sitting systolic bp 160-199 mmhg and sitting diastolic bp < 110 mmhg
boolean
C0005823 (UMLS CUI [1])
accelerated hypertension
Item
known accelerated hypertension (retinal haemorrhages or exudates or papilloedema).
boolean
C0020540 (UMLS CUI [1])
congestive heart failure, ace inhibitor, digoxin
Item
overt clinical congestive heart failure requiring treatment with a diuretic or angiotensin converting enzyme inhibitor. subjects allowed if treated with digoxin only.
boolean
C0018802 (UMLS CUI [1])
C0003015 (UMLS CUI [2])
C0012265 (UMLS CUI [3])
creatinine
Item
renal failure (serum creatinine of more than 150 µmol/l).
boolean
C0201976 (UMLS CUI [1])
subarachnoid haemorrhage
Item
previous documented cerebral or subarachnoid haemorrhage in the last 6 months. (ischaemic cerebral and cardiac events do not exclude, although the patient must be neurologically and cardiologically stable.)
boolean
C0038525 (UMLS CUI [1])
C2937358 (UMLS CUI [2])
comorbidity
Item
condition expected to severely limit survival, e.g. terminal illness.
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
secondary hypertension
Item
known secondary hypertension (e.g. renal artery stenosis, chronic renal insufficiency, and endocrine cause).
boolean
C0155616 (UMLS CUI [1])
gout
Item
gout.
boolean
C0018099 (UMLS CUI [1])
dementia
Item
clinical diagnosis of dementia.
boolean
C0497327 (UMLS CUI [1])
nursing home
Item
resident in a nursing home, i.e. where the dependency and care requirements of the patients are such that they require the regular input of qualified nurses and therefore the majority of staff in the home are nurses (other forms of residential care are acceptable).
boolean
C0028688 (UMLS CUI [1])
walking
Item
unable to stand up or walk
boolean
C0080331 (UMLS CUI [1])
study subject participation status
Item
participation in a drug trial within the past month preceding selection.
boolean
C2348568 (UMLS CUI [1])
substance abuse
Item
alcohol or drug abuse.
boolean
C0038586 (UMLS CUI [1])
placebo
Item
less than 2 months placebo run-in.
boolean
C0032042 (UMLS CUI [1])
contraindication
Item
contraindications to use of trial drugs
boolean
C1301624 (UMLS CUI [1])