age
Item
age 20-60 years;
boolean
C0001779 (UMLS CUI [1])
schizophrenia or schizoaffective disorder
Item
diagnosis of treatment refractory schizophrenia or schizoaffective disorder;
boolean
C0036341 (UMLS CUI [1])
C0036337 (UMLS CUI [2])
BPRS
Item
bprs score > 21 (0-6) scale;
boolean
C0029941 (UMLS CUI [1])
antipsychotic agents
Item
either two 6-8 week trials of typical neuroleptics given at a dosage of 600 mg/day of cpz or its equivalent or one 6-8 week trial of an atypical antipsychotic at a reasonable dose (i.e. risperidone 4-6 mg/day);
boolean
C0040615 (UMLS CUI [1])
informed consent
Item
the patient (or the patient's authorized legal representative) must understand the nature of the study and sign the informed consent;
boolean
C0021430 (UMLS CUI [1])
clozapine or olanzapine
Item
clinically appropriate for clozapine or olanzapine
boolean
C0009079 (UMLS CUI [1])
C0171023 (UMLS CUI [2])
substance abuse
Item
current substance abuse;
boolean
C0038586 (UMLS CUI [1])
suicide or homicide risk
Item
suicide or homicide risk;
boolean
C0038661 (UMLS CUI [1])
C0019872 (UMLS CUI [2])
pregnancy, lactation
Item
pregnancy or lactation;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
seizures, blood dyscrasias
Item
history of seizures or blood dyscrasias
boolean
C0036572 (UMLS CUI [1])
C0018939 (UMLS CUI [2])