subjects will be 144 smokers who have experienced at least one episode of major depressive disorder and 206 smokers who lack a lifetime history of major depressive disorder.
Item
subjects will be 144 smokers who have experienced at least one episode of major depressive disorder and 206 smokers who lack a lifetime history of major depressive disorder.
boolean
C0543414 (UMLS CUI [1])
C1269683 (UMLS CUI [2])
none will currently meet diagnostic criteria for major depression, nor will they have met criteria in the past 6 months.
Item
none will currently meet diagnostic criteria for major depression, nor will they have met criteria in the past 6 months.
boolean
C1269683 (UMLS CUI [1])
all will be male and female community members between the ages of 18 and 65 who have smoker at least 10 cigarettes a day for the past year.
Item
all will be male and female community members between the ages of 18 and 65 who have smoker at least 10 cigarettes a day for the past year.
boolean
C0001779 (UMLS CUI [1])
C0543414 (UMLS CUI [2])
1. have taken monoamine oxidase inhibitors, antidepressants, anti-anxiety agents, lithium, tryptophan or phenothiazines within the past month;
Item
1. have taken monoamine oxidase inhibitors, antidepressants, anti-anxiety agents, lithium, tryptophan or phenothiazines within the past month;
boolean
C0026457 (UMLS CUI [1])
C0003289 (UMLS CUI [2])
C0040616 (UMLS CUI [3])
C0023870 (UMLS CUI [4])
C0041249 (UMLS CUI [5])
C0031436 (UMLS CUI [6])
2. are being treated for hypertension with guanethidine, reserpine, thiazide diuretics, beta blockers, or clonidine;
Item
2. are being treated for hypertension with guanethidine, reserpine, thiazide diuretics, beta blockers, or clonidine;
boolean
C0020538 (UMLS CUI [1])
C0018318 (UMLS CUI [2])
C0035179 (UMLS CUI [3])
C0541746 (UMLS CUI [4])
C0304516 (UMLS CUI [5])
C0009014 (UMLS CUI [6])
3. are taking type ic antiarrhythmics (e.g., propafenone and flecanide) or a highly protein-bound drug (e.g., warfarin, digitoxin);
Item
3. are taking type ic antiarrhythmics (e.g., propafenone and flecanide) or a highly protein-bound drug (e.g., warfarin, digitoxin);
boolean
C0003195 (UMLS CUI [1])
C0043031 (UMLS CUI [2])
C0012258 (UMLS CUI [3])
4. have a medically unstable condition or had a major health event in the past 6 months (e.g., myocardial infarct or major surgery);
Item
4. have a medically unstable condition or had a major health event in the past 6 months (e.g., myocardial infarct or major surgery);
boolean
C0009488 (UMLS CUI [1])
5. have cbc values more than 10% outside the normal limits, or liver enzymes exceeding 40% of the upper limit of normal;
Item
5. have cbc values more than 10% outside the normal limits, or liver enzymes exceeding 40% of the upper limit of normal;
boolean
C0009555 (UMLS CUI [1])
C1287351 (UMLS CUI [2])
6. have a history of severe allergies, multiple adverse drug reactions or known allergy to fluoxetine;
Item
6. have a history of severe allergies, multiple adverse drug reactions or known allergy to fluoxetine;
boolean
C0020517 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C0016365 (UMLS CUI [2,2])
7. are actively abusing alcohol or drugs or received inpatient treatment for substance abuse within the past year;
Item
7. are actively abusing alcohol or drugs or received inpatient treatment for substance abuse within the past year;
boolean
C0038586 (UMLS CUI [1])
8. are using nicotine replacements;
Item
8. are using nicotine replacements;
boolean
C1278444 (UMLS CUI [1])
9. are pregnant, lactating, or of childbearing potential;
Item
9. are pregnant, lactating, or of childbearing potential;
boolean
C0032961 (UMLS CUI [1])
10. present current evidence of organic brain disease, definite or subclinical major depressive disorder or serious suicidal risk post-traumatic stress disorder, or premenstrual dysphoric disorder;
Item
10. present current evidence of organic brain disease, definite or subclinical major depressive disorder or serious suicidal risk post-traumatic stress disorder, or premenstrual dysphoric disorder;
boolean
C0009488 (UMLS CUI [1])
11. have a score greater than 14 on the 21-item hamilton depression rating scale or greater than 15 on the beck depression inventory;
Item
11. have a score greater than 14 on the 21-item hamilton depression rating scale or greater than 15 on the beck depression inventory;
boolean
C0451203 (UMLS CUI [1])
C0451022 (UMLS CUI [2])
12. have a history of seizures, mania or hypomania, or psychosis. individuals with bipolar disorder, ptsd, or schizophrenia will be excluded because they might respond adversely to fluoxetine.
Item
12. have a history of seizures, mania or hypomania, or psychosis. individuals with bipolar disorder, ptsd, or schizophrenia will be excluded because they might respond adversely to fluoxetine.
boolean
C0009488 (UMLS CUI [1])
subjects with dysthymic disorder or anxiety disorders will be studied if their current symptoms are not sequelae of an episode of major depression. excluding such cases would purify the sample by removing mild degrees of dysphoria, but would greatly restrict our ability to generalize any treatment implications to the current population that smokers.
Item
subjects with dysthymic disorder or anxiety disorders will be studied if their current symptoms are not sequelae of an episode of major depression. excluding such cases would purify the sample by removing mild degrees of dysphoria, but would greatly restrict our ability to generalize any treatment implications to the current population that smokers.
boolean
C0009488 (UMLS CUI [1])