myelodysplastic syndrome, myeloid leukemia
Item
patients must have pathologically documented myelodysplasia or acute myelogenous leukemia.
boolean
C3463824 (UMLS CUI [1])
C0023467 (UMLS CUI [2])
inclusion myelodysplastic syndrome
Item
the patients with myelodysplasia must also have: french-american-british (fab) subtype refractory anemia with excess blasts (raeb) or refractory anemia with excess blasts in transformation (raeb-t), or normal or hypercellular bone marrow.
boolean
C3463824 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C2984084 (UMLS CUI [2])
C0005953 (UMLS CUI [3])
inclusion acute myelogenous leukemia
Item
the patients with acute myelogenous leukemia must also: not be candidates for myelosuppressive chemotherapy due to age or comorbid disease, or have relapsed acute myelogenous leukemia or be refractory to standard therapy and not likely to require cytoreductive therapy within 60 days
boolean
C0023467 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0392920 (UMLS CUI [2])
C0277556 (UMLS CUI [3])
C0205269 (UMLS CUI [4])
ecog performance status
Item
eastern cooperative oncology group (ecog) performance status 0 or 1.
boolean
C1520224 (UMLS CUI [1])
life expectancy
Item
estimated life expectancy of 6 months or greater.
boolean
C0023671 (UMLS CUI [1])
age
Item
age at least 18 years.
boolean
C0001779 (UMLS CUI [1])
therapy
Item
greater than 4 weeks from any chemotherapy, radiotherapy, immunotherapy, or systemic glucocorticoid therapy (non-glucocorticoid hormonal therapy allowed).
boolean
C0087111 (UMLS CUI [1])
stem cell transplant, dli
Item
greater than 2 months following bone marrow or peripheral blood stem cell transplantation or treatment with donor lymphocyte infusion (dli).
boolean
C1504389 (UMLS CUI [1])
C1512034 (UMLS CUI [2])
comorbidity
Item
uncontrolled active infection.
boolean
C0009488 (UMLS CUI [1,1])
C0517627 (UMLS CUI [1,2])
pregnancy, breastfeeding
Item
pregnancy or nursing mothers.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
study subject participation status
Item
previous participation in an adenovirus based trial.
boolean
C2348568 (UMLS CUI [1])
exclusion myelodysplastic syndrome
Item
the patients with myelodysplasia who have either: fab subtype refractory anemia (ra), refractory anemia with ringed sideroblasts (rars), chronic myelomonocytic leukemia (cmml), or the presence of hypocellular bone marrow.
boolean
C0680251 (UMLS CUI [1,1])
C3463824 (UMLS CUI [1,2])
C2984084 (UMLS CUI [2])
C0005953 (UMLS CUI [3])
therapy
Item
chemotherapy, radiotherapy, immunotherapy, or systemic steroid therapy within the last 4 weeks.
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
C0038317 (UMLS CUI [4])
comorbidity
Item
active central nervous system (cns) disease.
boolean
C0009488 (UMLS CUI [1,1])
C0007682 (UMLS CUI [1,2])
comorbidity
Item
evidence of infection with the human immunodeficiency virus.
boolean
C0009488 (UMLS CUI [1,1])
C0019682 (UMLS CUI [1,2])
comorbidity
Item
active psychiatric or mental illness making informed consent or careful clinical follow-up unlikely.
boolean
C0009488 (UMLS CUI [1,1])
C0004936 (UMLS CUI [1,2])