lack of suitable stem cell donor or rapidly progressive disease
Item
lack of suitable conventional donor (i.e. 7/8 or 8/8 related or 7/8 or 8/8 unrelated donor) or presence of rapidly progressive disease not permitting time to identify an unrelated donor
boolean
C0375877 (UMLS CUI [1])
C0677932 (UMLS CUI [2])
hla typing
Item
hla typing will be performed at high resolution (allele level) for the hla-a, -b, cw, and drbl, and loci. a minimum match of 5/10 is required. the donor and recipient must be identical, as determined by high resolution typing, at least one allele of each of the following genetic loci: hla-a, hla-b, hla-cw, and hla- drb1.
boolean
C0242318 (UMLS CUI [1])
adequate physical function
Item
subjects with adequate physical function as measured by:a)cardiac: left ventricular ejection fraction at rest must be >35 percent, or shortening fraction > 25percent. b)hepatic: bilirubin < 2.5 mg/dl; and alt, ast, and alkaline phosphatase < 5 x uln. c)renal: serum creatinine within normal range for age, or creatinine clearance or gfr > 40 ml/min/1.73m2. d)pulmonary: fev 1, fvc, dlco (diffusion capacity) > 50 percent predicted (corrected for hemoglobin); or 02 saturation > 92 percent on room air.
boolean
C0231162 (UMLS CUI [1])
acute lymphoblastic leukemia, acute myelogenous leukemia, lymphoma
Item
clinical diagnosis of one of the following: acute lymphoblastic leukemia, acute myelogenous leukemia, lymphoma
boolean
C0023449 (UMLS CUI [1])
C0023467 (UMLS CUI [2])
C0024299 (UMLS CUI [3])
chemotherapy
Item
subjects must have received cytotoxic chemotherapy within 3 months of consent date (measured from the start date of chemotherapy).
boolean
C0392920 (UMLS CUI [1])
karnofsky performance
Item
performance status: karnofsky/lansky score > 60 percent.
boolean
C0206065 (UMLS CUI [1])
stem cell donor available
Item
hla-matched, related or 7-or 8/8 allele matched (hla-a,-b,-cw,-drbl) unrelated donor able to donate.
boolean
C0375877 (UMLS CUI [1,1])
C0470187 (UMLS CUI [1,2])
autologous hematopoietic stem cell transplant
Item
autologous hematopoietic stem cell transplant < 3 months prior to enrollment.
boolean
C1831743 (UMLS CUI [1])
pregnant or breastfeeding
Item
pregnancy or breast-feeding.
boolean
C0549206 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
hiv positivity
Item
evidence of hiv infection or known hiv positive serology.
boolean
C0019699 (UMLS CUI [1])
current uncontrolled bacterial, viral or fungal infection
Item
current uncontrolled bacterial, viral or fungal infection (currently taking medication with evidence of progression of clinical symptoms or radiologic findings).
boolean
C0004623 (UMLS CUI [1])
C0042769 (UMLS CUI [2])
C0026946 (UMLS CUI [3])
non-hematologic malignancy
Item
non-hematologic malignancy within prior three (3) years.
boolean
C0935681 (UMLS CUI [1])
allogeneic hematopoietic stem cell transplant
Item
prior allogeneic hematopoietic stem cell transplant.
boolean
C2242529 (UMLS CUI [1])
idiopathic myelofibrosis
Item
subjects with a history of primary idiopathic myelofibrosis.
boolean
C0001815 (UMLS CUI [1])
bovine product allergy
Item
bovine product allergy.
boolean
C0020517 (UMLS CUI [1])
C0036774 (UMLS CUI [2])