all
Item
have a diagnosis of all and confirmed by pathologic assessment.
boolean
C0023449 (UMLS CUI [1])
age
Item
be ≤ 21 years old at time of initial diagnosis.
boolean
C0001779 (UMLS CUI [1])
primary refractory disease
Item
eligible patients must have: primary refractory disease; or relapsed or refractory disease after a minimum of 2 prior blocks of treatment.
boolean
C1514815 (UMLS CUI [1])
must not be eligible for therapy of higher curative potential
Item
must not be eligible for therapy of higher curative potential.
boolean
C0040808 (UMLS CUI [1])
C3242266 (UMLS CUI [2])
karnofsky performance status
Item
have a karnofsky performance status of ≥ 50 or lansky performance scale of ≥ 30.
boolean
C0206065 (UMLS CUI [1])
informed consent
Item
provide a signed, written informed consent from parent or guardian or young adult patients.
boolean
C0021430 (UMLS CUI [1])
compliance behavior
Item
be able to comply with study procedures and follow-up examinations.
boolean
C1321605 (UMLS CUI [1])
cardiac function
Item
have adequate cardiac function without treatment.
boolean
C0232164 (UMLS CUI [1])
organ function
Item
have adequate organ function as indicated by the laboratory values for serum creatinine, serum bilirubin, ast and alt, obtained within 7 days prior to registration.
boolean
C0678852 (UMLS CUI [1])
previous treatment
Item
received previous treatment with clofarabine.
boolean
C1514463 (UMLS CUI [1])
C0092777 (UMLS CUI [2])
extramedullary disease
Item
patients with isolated extramedullary disease.
boolean
C1868812 (UMLS CUI [1])
have received prior bmt or pbsct
Item
have received prior bmt or pbsct within the last 6 months.
boolean
C0005961 (UMLS CUI [1])
C1519005 (UMLS CUI [2])
have received prior bmt or pbsct more than 6 months ago, but now has compromised organ function
Item
have received prior bmt or pbsct more than 6 months ago, but now has compromised organ function.
boolean
C0005961 (UMLS CUI [1])
C1519005 (UMLS CUI [2])
C2015897 (UMLS CUI [3])
systemic infection
Item
have an active, uncontrolled systemic infection.
boolean
C0243026 (UMLS CUI [1])
pregnant or breastfeeding, contraception
Item
are pregnant or lactating. male and female patients who are fertile must agree to use an effective means of birth control to avoid pregnancy.
boolean
C0549206 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0700589 (UMLS CUI [3])
have a psychiatric disorder that would interfere with consent, study participation, or follow-up
Item
have a psychiatric disorder that would interfere with consent, study participation, or follow-up.
boolean
C0021430 (UMLS CUI [1])
C0439801 (UMLS CUI [2])
C0009488 (UMLS CUI [3])
chemotherapy
Item
have received any other chemotherapy within the previous 2 weeks and must have recovered from acute toxicity oa all previous therapy prior to enrollment.
boolean
C0392920 (UMLS CUI [1])
Comorbidity
Item
have any other severe concurrent disease.
boolean
C0009488 (UMLS CUI [1])
organ dysfunction
Item
have recent history of significant renal, hepatic or pulmonary dysfunction, or cardiac dysfunction or on treatment to support cardiac function.
boolean
C3279454 (UMLS CUI [1])
C0086565 (UMLS CUI [2])
C1709770 (UMLS CUI [3])
C3277906 (UMLS CUI [4])
cns disease
Item
have cns disease.
boolean
C0007682 (UMLS CUI [1])