age
Item
> 18 years of age
boolean
C0001779 (UMLS CUI [1])
hospital admission for acute heart failure
Item
hospital admission for acute heart failure as defined by the presence of acute dyspnea and the presence of clinical signs of heart failure on physical examination.
boolean
C0264714 (UMLS CUI [1])
C0019993 (UMLS CUI [2])
where available, nt-probnp >900 pg/ml, >1800 pg/ml if the patient has atrial fibrillation at screening or >450 pg/ml if bmi > 35 kg/m2, lvef <45 percent assessed by echocardiography or other method within the previous 12 months
Item
where available, nt-probnp >900 pg/ml, >1800 pg/ml if the patient has atrial fibrillation at screening or >450 pg/ml if bmi > 35 kg/m2, lvef <45 percent assessed by echocardiography or other method within the previous 12 months
boolean
C3272900 (UMLS CUI [1])
C0004238 (UMLS CUI [2])
C0428772 (UMLS CUI [3])
background therapy with at least ace-inhibitor or angiotensin receptor blocker (arb) and beta-blocker (unless beta-blocker is contraindicated due to severe volume overload, low output heart failure, or cardiogenic shock)
Item
background therapy with at least ace-inhibitor or angiotensin receptor blocker (arb) and beta-blocker (unless beta-blocker is contraindicated due to severe volume overload, low output heart failure, or cardiogenic shock)
boolean
C0003015 (UMLS CUI [1])
C0521942 (UMLS CUI [2])
follow up
Item
available for regular follow up
boolean
C0589120 (UMLS CUI [1])
currently being treated with hydralazine and/or nitrates or a history of intolerance to oral therapy with either hydralazine or nitrates.
Item
currently being treated with hydralazine and/or nitrates or a history of intolerance to oral therapy with either hydralazine or nitrates.
boolean
C0020223 (UMLS CUI [1])
C2321306 (UMLS CUI [2])
any intravenous treatment for heart failure, except iv furosemide (eg. iv inotropes, pressors, nitrates or nesiritide) at the time of screening
Item
any intravenous treatment for heart failure, except iv furosemide (eg. iv inotropes, pressors, nitrates or nesiritide) at the time of screening.
boolean
C2347852 (UMLS CUI [1])
systolic blood pressure <100 mmhg
Item
systolic blood pressure <100 mmhg
boolean
C0020649 (UMLS CUI [1])
plan for revascularization
Item
plan for revascularization
boolean
C0581603 (UMLS CUI [1])
greater than 96 hours after admission
Item
greater than 96 hours after admission
boolean
C1320532 (UMLS CUI [1])
reversible etiology of acute heart failure
Item
reversible etiology of acute heart failure such as myocarditis, acute myocardial infarction, arrhythmia. acute mi is defined as symptoms and major electrocardiogram (ecg) changes(i.e., st segment elevations), and arrhythmia includes unstable heart rates above 120/min or below 50/min.
boolean
C0027059 (UMLS CUI [1])
C0155626 (UMLS CUI [2])
C0003811 (UMLS CUI [3])
hypertrophic obstructive cardiomyopathy, constrictive cardiomyopathy, endomyocardial fibroelastosis
Item
hypertrophic obstructive cardiomyopathy, constrictive cardiomyopathy, endomyocardial fibroelastosis
boolean
C0878544 (UMLS CUI [1])
C0014117 (UMLS CUI [2])
severe congenital heart disease
Item
known severe congenital heart disease (such as uncorrected tetralogy of fallot or transposition of the aorta)
boolean
C0152021 (UMLS CUI [1])
severe aortic or mitral stenosis or severe rheumatic mitral regurgitation
Item
severe aortic or mitral stenosis or severe rheumatic mitral regurgitation.
boolean
C0155572 (UMLS CUI [1])
C0155563 (UMLS CUI [2])
renal impairment
Item
renal impairment (defined by creatinine >3 mg/dl) at screening or on any type of dialysis.
boolean
C1565489 (UMLS CUI [1])
hepatic impairment
Item
known hepatic impairment (total bilirubin >3mg/dl) or increased ammonia levels at screening.
boolean
C0948807 (UMLS CUI [1])
systemic lupus erythematous
Item
history of systemic lupus erythematous.
boolean
C0024141 (UMLS CUI [1])
stroke or tia within 2 weeks from screening.
Item
stroke or tia within 2 weeks from screening.
boolean
C0038454 (UMLS CUI [1])
C0007787 (UMLS CUI [2])
pregnant or breastfeeding
Item
women who are pregnant or lactating.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
allergy to organic nitrates
Item
allergy to organic nitrates
boolean
C0020517 (UMLS CUI [1])
C3654024 (UMLS CUI [2])
history or presence of any other diseases (ie. including malignancies or aids) with a life expectancy of < 12 months
Item
history or presence of any other diseases (ie. including malignancies or aids) with a life expectancy of < 12 months
boolean
C0023671 (UMLS CUI [1])