v600e mutation
Item
presence of braf v600e mutation in tumor tissue
boolean
C3811884 (UMLS CUI [1])
stage iiib or iv nsclc
Item
histologically or cytologically confirmed diagnosis of stage iiib or iv nsclc
boolean
C0278984 (UMLS CUI [1])
C0278987 (UMLS CUI [2])
measurable lesion as defined by recist
Item
at least one measurable lesion as defined by recist v1.1
boolean
C0221198 (UMLS CUI [1,1])
C1513040 (UMLS CUI [1,2])
C1709926 (UMLS CUI [1,3])
systemic, anti-cancer treatment; advanced or metastatic nsclc
Item
patients must have progressed during or after at least one previous systemic, anti-cancer treatment for locally advanced or metastatic nsclc.
boolean
C1515119 (UMLS CUI [1,1])
C0920425 (UMLS CUI [1,2])
eastern cooperative oncology group; performance status
Item
eastern cooperative oncology group (ecog)/world health organization (who) performance status 0-2
boolean
C1520224 (UMLS CUI [1])
symptomatic central nervous system involvement; metastases; cns
Item
patients with symptomatic central nervous system (cns) metastases
boolean
C0686377 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
leptomeningeal metastases
Item
history of leptomeningeal metastases
boolean
C1704231 (UMLS CUI [1])
prior therapy
Item
prior therapy with a braf inhibitor
boolean
C3838813 (UMLS CUI [1])
medication; protocol
Item
patients taking prohibited medication listed in the protocol
boolean
C0525058 (UMLS CUI [1])
malignant disease other than nsclc
Item
presence or history of a malignant disease other than nsclc that has been diagnosed and/or required therapy within the past 3 years.
boolean
C0006826 (UMLS CUI [1])
significant cardiovascular diseases
Item
impaired cardiovascular function or clinically significant cardiovascular diseases
boolean
C0007222 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
pregnant or lactating women of childbearing potential
Item
pregnant or lactating women or woman of childbearing potential
boolean
C0549206 (UMLS CUI [1,1])
|C2828358|C3831118 (UMLS CUI [1,2])