evidence of progression; progression of disease; diagnosis; probable
Item
diagnosis of probable alzheimer disease (ad) with documented evidence of progression of disease
boolean
C1457887 (UMLS CUI [1,1])
C1301725 (UMLS CUI [1,2])
C0332307 (UMLS CUI [1,3])
C0242656 (UMLS CUI [2])
C0011900 (UMLS CUI [3])
C1709683 (UMLS CUI [4])
examination; score; mental; state
Item
mini mental state examination (mmse) score of 21-26, inclusive
boolean
C0260877 (UMLS CUI [1])
C0449820 (UMLS CUI [2])
C0004936 (UMLS CUI [3])
C1442065 (UMLS CUI [4,1])
C0805701 (UMLS CUI [4,2])
C0027361 (UMLS CUI [4,3])
clinical; dementia; score
Item
clinical dementia rating global score of 0.5 or 1
boolean
C0205210 (UMLS CUI [1])
C0497327 (UMLS CUI [2])
C0449820 (UMLS CUI [3])
ischemia; score
Item
rosen-modified hachinski ischemia score less than or equal to 4
boolean
C0340561 (UMLS CUI [1])
C0449820 (UMLS CUI [2])
magnetic resonance imaging; diagnosis; probable; brain; mri
Item
brain magnetic resonance imaging (mri) consistent with the diagnosis of probable ad
boolean
C0024485 (UMLS CUI [1])
C0011900 (UMLS CUI [2])
C1709683 (UMLS CUI [3])
C0006104 (UMLS CUI [4])
C0024485 (UMLS CUI [5])
cholinesterase; randomization; memantine; stable; dose
Item
concurrent use of cholinesterase inhibitor or memantine with stable dose for at least 3 months prior to randomization
boolean
C0202207 (UMLS CUI [1])
C1522541 (UMLS CUI [2,1])
C1515944 (UMLS CUI [2,2])
C0332307 (UMLS CUI [2,3])
C0034656 (UMLS CUI [2,4])
C0025242 (UMLS CUI [3])
C0205360 (UMLS CUI [4])
C3174092 (UMLS CUI [5])
no code found
Item
caregiver willing to participate and be able to attend clinic visits with patient
boolean
medications; oral
Item
ability to ingest oral medications
boolean
C0488501 (UMLS CUI [1])
C0442027 (UMLS CUI [2])
alzheimer's disease; neurological; other
Item
significant neurological or psychiatric disease other than alzheimer's disease
boolean
C0002395 (UMLS CUI [1])
C0449438 (UMLS CUI [2,1])
C0205494 (UMLS CUI [2,2])
C0031809 (UMLS CUI [2,3])
C0030705 (UMLS CUI [2,4])
C1533734 (UMLS CUI [3,1])
C1512699 (UMLS CUI [3,2])
C0205394 (UMLS CUI [3,3])
C0013227 (UMLS CUI [3,4])
participants; allergies; dyspnea; severe; drug; rash
Item
participants with evidence or history of severe drug allergies (resulting in dyspnea or severe rash).
boolean
CL106596 (UMLS CUI [1])
C0020517 (UMLS CUI [2])
C0013404 (UMLS CUI [3])
C0205082 (UMLS CUI [4])
C0013227 (UMLS CUI [5])
C0015230 (UMLS CUI [6])
clinically significant; computed tomography; contraindications; mri; non
Item
any contraindications to mri (e.g., clinically significant claustrophobia, non-removable ferromagnetic implants). patients with contraindications to mri may undergo computed tomography (ct) on approval by sponsor.
boolean
C2826633 (UMLS CUI [1])
C0040405 (UMLS CUI [2])
C0522473 (UMLS CUI [3,1])
C0003015 (UMLS CUI [3,2])
C0024485 (UMLS CUI [4])
C3530214 (UMLS CUI [5])
contraindications; component; pet scan; allergy; cohort; study; dose
Item
any contraindications to the fdg-pet study (e.g. allergy to any component of the fdg dose) in the cohort undergoing a pet scan.
boolean
C0522473 (UMLS CUI [1,1])
C0003015 (UMLS CUI [1,2])
C0027651 (UMLS CUI [2,1])
C0027365 (UMLS CUI [2,2])
C0008902 (UMLS CUI [2,3])
C0032743 (UMLS CUI [3])
C0020517 (UMLS CUI [4])
C1881010 (UMLS CUI [5,1])
C0332307 (UMLS CUI [5,2])
C0205390 (UMLS CUI [5,3])
C0008976 (UMLS CUI [6])
C3174092 (UMLS CUI [7])
alzheimer's disease; screening; therapies; exposure; non
Item
previous exposure to investigational or non-investigational therapies for alzheimer's disease within 6 months of screening
boolean
C0002395 (UMLS CUI [1])
C1409616 (UMLS CUI [2])
C0087111 (UMLS CUI [3])
C0332157 (UMLS CUI [4])
C3530214 (UMLS CUI [5])
prostate; treatment; cutaneous; cervical; squamous; cancer; last; non
Item
history of cancer within the last 5 years except adequately treated cervical carcinoma in-situ, cutaneous basal cell or squamous cell cancer, or non-progressive prostate cancer not requiring treatment
boolean
C0033572 (UMLS CUI [1])
C0087111 (UMLS CUI [2])
C0221912 (UMLS CUI [3])
C0205064 (UMLS CUI [4])
C1182670 (UMLS CUI [5])
C0006826 (UMLS CUI [6])
C2986440 (UMLS CUI [7,1])
C1517741 (UMLS CUI [7,2])
C3530214 (UMLS CUI [8])
childbearing potential
Item
women of childbearing potential
boolean
C1960468 (UMLS CUI [1])
blood pressure
Item
uncontrolled blood pressure and/or blood pressure above 160/100
boolean
C0005823 (UMLS CUI [1])
alzheimer's disease; prescription; food
Item
prescription medical food intended for dietary management of the metabolic processes associated with alzheimer's disease.
boolean
C0002395 (UMLS CUI [1])
C1521941 (UMLS CUI [2])
C0016452 (UMLS CUI [3])