ID

16928

Description

NINDS Common Data Elements, Multiple Sclerosis Biospecimens Summary Statement Appendix B – Potential MS Biomarkers Used from the National Institute of Neurological Disorders and Stroke Common Data Elements (https://www.commondataelements.ninds.nih.gov/) References: Grinnon ST, Miller K, Marler JR, Lu Y, Stout A, Odenkirchen J, Kunitz S. National Institute of Neurological Disorders and Stroke Common Data Element Project - approach and methods. Clin Trials. 2012;9(3):322-9.

Link

https://www.commondataelements.ninds.nih.gov/

Keywords

Versions (2)
  1. 8/14/16 8/14/16 -
  2. 9/17/21 9/17/21 -
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August 14, 2016

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NINDS CDE Biospecimens Summary Statement Multiple Sclerosis

English

Biospecimens Summary Statement Appendix B – Potential MS Biomarkers

1 forms  
Potential serum biomarkers of disease activity in MS
Description

Potential serum biomarkers of disease activity in MS

Alias
UMLS CUI-1
C0005516
UMLS CUI-2
C0229671
UMLS CUI-3
C0026769
TNF-α
Description

TNF-α

Data type

text

Alias
UMLS CUI [1]
C1456820
IL-10
Description

IL-10

Data type

text

Alias
UMLS CUI [1]
C0085295
IL-12p40
Description

IL-12p40

Data type

text

Alias
UMLS CUI [1]
C1121402
IL-17
Description

IL-17

Data type

text

Alias
UMLS CUI [1]
C0384648
IFN-γ
Description

IFN-γ

Data type

text

Alias
UMLS CUI [1,1]
C0021747
UMLS CUI [1,2]
C2349976
Osteopontin
Description

Osteopontin

Data type

text

Alias
UMLS CUI [1]
C0069676
IL-6
Description

IL-6

Data type

text

Alias
UMLS CUI [1]
C0021760
Cell surface biomarkers
Description

Cell surface biomarkers

Alias
UMLS CUI-1
C0005516
UMLS CUI-2
C0699040
K2P5.1 + T cells
Description

K2P5.1; T cells

Data type

text

Alias
UMLS CUI [1,1]
C1456384
UMLS CUI [1,2]
C0039194
IFN-γ Receptor-β
Description

IFN-γ

Data type

text

Alias
UMLS CUI [1,1]
C0021747
UMLS CUI [1,2]
C2349976
IFN-α Receptor-2
Description

IFN-α

Data type

text

Alias
UMLS CUI [1]
C0002199
CD56bright NK cells
Description

CD56

Data type

text

Alias
UMLS CUI [1]
C0108754
CD8 + CD25 + FoxP3 + Treg cells
Description

CD8+; CD25 +; FoxP3; Treg cells

Data type

text

Alias
UMLS CUI [1]
C0085358
UMLS CUI [2]
C0007507
UMLS CUI [3]
C1976944
UMLS CUI [4]
C0039198
Fas/FasL
Description

Fas/FasL

Data type

text

Alias
UMLS CUI [1]
C3546404
CD80
Description

CD80

Data type

text

Alias
UMLS CUI [1]
C0104998
CD86
Description

CD86

Data type

text

Alias
UMLS CUI [1]
C0527903
CD40
Description

CD40

Data type

text

Alias
UMLS CUI [1]
C0054959
PD1/PDL1
Description

PD1/PDL1

Data type

text

PDL2
Description

PDL2

Data type

text

Alias
UMLS CUI [1]
C1705357
Survivin
Description

Survivin

Data type

text

Alias
UMLS CUI [1]
C1515097
Potential humoral and antibody biomarkers
Description

Potential humoral and antibody biomarkers

Alias
UMLS CUI-1
C0005516
UMLS CUI-2
C0020967
UMLS CUI-3
C0003241
OCB
Description

OCB

Data type

text

Aquaporin-4 (NMO) antibody
Description

Aquaporin-4 antibody

Data type

text

Alias
UMLS CUI [1]
C2919772
IFN-β Neutralizing antibodies
Description

Interferon beta antibody

Data type

text

Alias
UMLS CUI [1]
C0946148
CD19 + CD138 + B cells
Description

CD19; B cells

Data type

text

Alias
UMLS CUI [1]
C0108748
UMLS CUI [2]
C0004561
MOG/MBP antibodies
Description

MOG/MBP antibodies

Data type

text

CD46/59 antibodies
Description

CD46/59 antibodies

Data type

text

Complement factor H
Description

Complement factor H

Data type

text

Alias
UMLS CUI [1]
C0056207
C4 fragment
Description

fragment

Data type

text

EBNA IgG
Description

EBNA IgG

Data type

text

Alias
UMLS CUI [1]
C2208765
Ig kappa light chains
Description

Ig kappa light chains

Data type

text

Alias
UMLS CUI [1]
C0021036
Biomarkers related to adhesion and migration
Description

Biomarkers related to adhesion and migration

Alias
UMLS CUI-1
C0005516
UMLS CUI-2
C0007577
UMLS CUI-3
C1622501
sVCAM
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C0007578
LFA1
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C0079717
VLA4
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C0209606
MMP9
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C0165519
TIMP1
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C0145947
MMP-8
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C0172956
IL-8
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C0079633
IP-10
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C1308752
CXCL8
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C1698756
CCL2
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C1449159
CCL5
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C1436337
CXCR3
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C1741914
CXCL13
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C0963811
CCR5
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C3711103
CX3CR1
Description

Source: Serum and CSF

Data type

text

Alias
UMLS CUI [1]
C1143767
ICAM
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0598077
CXCL12
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C1528383
NCAM
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0282587
Biomarkers of tissue damage and repair
Description

Biomarkers of tissue damage and repair

Alias
UMLS CUI-1
C0005516
UMLS CUI-2
C0010957
UMLS CUI-3
C1705181
Neurofilament chains
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0027834
GFAP
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0017626
S100
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0027758
NAA
Description

Source: CSF/MRS

Data type

text

Alias
UMLS CUI [1]
C0067684
Nitric oxide products
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0028128
Pentosidine
Description

Source: Serum

Data type

text

Alias
UMLS CUI [1]
C0070317
BDNF
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0107103
CNTF
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0207071
GDNF
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0207072
NGF
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0027752
NT3
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C0083735
NT4
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C1623464
Other potential biomarkers
Description

Other potential biomarkers

Alias
UMLS CUI-1
C0005516
UMLS CUI-2
C0205394
Myxovirus resistance protein A
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C3711733
Myoinositol
Description

Source: CSF/MRS

Data type

text

Alias
UMLS CUI [1]
C0021547
Bri2-23
Description

Source: CSF

Data type

text

Fetuin-A
Description

Source: CSF

Data type

text

Alias
UMLS CUI [1]
C3178998
ILT3
Description

Source: PBMC

Data type

text

Alias
UMLS CUI [1]
C0539587
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Similar models

Biospecimens Summary Statement Appendix B – Potential MS Biomarkers

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Potential serum biomarkers of disease activity in MS
C0005516 (UMLS CUI-1)
C0229671 (UMLS CUI-2)
C0026769 (UMLS CUI-3)
TNF-α
Item
TNF-α
text
C1456820 (UMLS CUI [1])
IL-10
Item
IL-10
text
C0085295 (UMLS CUI [1])
IL-12p40
Item
IL-12p40
text
C1121402 (UMLS CUI [1])
IL-17
Item
IL-17
text
C0384648 (UMLS CUI [1])
IFN-γ
Item
IFN-γ
text
C0021747 (UMLS CUI [1,1])
C2349976 (UMLS CUI [1,2])
Osteopontin
Item
Osteopontin
text
C0069676 (UMLS CUI [1])
IL-6
Item
IL-6
text
C0021760 (UMLS CUI [1])
Item Group
Cell surface biomarkers
C0005516 (UMLS CUI-1)
C0699040 (UMLS CUI-2)
K2P5.1; T cells
Item
K2P5.1 + T cells
text
C1456384 (UMLS CUI [1,1])
C0039194 (UMLS CUI [1,2])
IFN-γ
Item
IFN-γ Receptor-β
text
C0021747 (UMLS CUI [1,1])
C2349976 (UMLS CUI [1,2])
IFN-α
Item
IFN-α Receptor-2
text
C0002199 (UMLS CUI [1])
CD56
Item
CD56bright NK cells
text
C0108754 (UMLS CUI [1])
CD8+; CD25 +; FoxP3; Treg cells
Item
CD8 + CD25 + FoxP3 + Treg cells
text
C0085358 (UMLS CUI [1])
C0007507 (UMLS CUI [2])
C1976944 (UMLS CUI [3])
C0039198 (UMLS CUI [4])
Fas/FasL
Item
Fas/FasL
text
C3546404 (UMLS CUI [1])
CD80
Item
CD80
text
C0104998 (UMLS CUI [1])
CD86
Item
CD86
text
C0527903 (UMLS CUI [1])
CD40
Item
CD40
text
C0054959 (UMLS CUI [1])
PD1/PDL1
Item
PD1/PDL1
text
PDL2
Item
PDL2
text
C1705357 (UMLS CUI [1])
Survivin
Item
Survivin
text
C1515097 (UMLS CUI [1])
Item Group
Potential humoral and antibody biomarkers
C0005516 (UMLS CUI-1)
C0020967 (UMLS CUI-2)
C0003241 (UMLS CUI-3)
OCB
Item
OCB
text
Aquaporin-4 antibody
Item
Aquaporin-4 (NMO) antibody
text
C2919772 (UMLS CUI [1])
Interferon beta antibody
Item
IFN-β Neutralizing antibodies
text
C0946148 (UMLS CUI [1])
CD19; B cells
Item
CD19 + CD138 + B cells
text
C0108748 (UMLS CUI [1])
C0004561 (UMLS CUI [2])
MOG/MBP antibodies
Item
MOG/MBP antibodies
text
CD46/59 antibodies
Item
CD46/59 antibodies
text
Complement factor H
Item
Complement factor H
text
C0056207 (UMLS CUI [1])
fragment
Item
C4 fragment
text
EBNA IgG
Item
EBNA IgG
text
C2208765 (UMLS CUI [1])
Ig kappa light chains
Item
Ig kappa light chains
text
C0021036 (UMLS CUI [1])
Item Group
Biomarkers related to adhesion and migration
C0005516 (UMLS CUI-1)
C0007577 (UMLS CUI-2)
C1622501 (UMLS CUI-3)
Cell Adhesion Molecules
Item
sVCAM
text
C0007578 (UMLS CUI [1])
LFA1
Item
LFA1
text
C0079717 (UMLS CUI [1])
VLA4
Item
VLA4
text
C0209606 (UMLS CUI [1])
MMP9
Item
MMP9
text
C0165519 (UMLS CUI [1])
TIMP1
Item
TIMP1
text
C0145947 (UMLS CUI [1])
MMP-8
Item
MMP-8
text
C0172956 (UMLS CUI [1])
IL-8
Item
IL-8
text
C0079633 (UMLS CUI [1])
IP-10
Item
IP-10
text
C1308752 (UMLS CUI [1])
CXCL8
Item
CXCL8
text
C1698756 (UMLS CUI [1])
CCL2
Item
CCL2
text
C1449159 (UMLS CUI [1])
CCL5
Item
CCL5
text
C1436337 (UMLS CUI [1])
CXCR3
Item
CXCR3
text
C1741914 (UMLS CUI [1])
CXCL13
Item
CXCL13
text
C0963811 (UMLS CUI [1])
CCR5
Item
CCR5
text
C3711103 (UMLS CUI [1])
CX3CR1
Item
CX3CR1
text
C1143767 (UMLS CUI [1])
ICAM
Item
ICAM
text
C0598077 (UMLS CUI [1])
CXCL12
Item
CXCL12
text
C1528383 (UMLS CUI [1])
NCAM
Item
NCAM
text
C0282587 (UMLS CUI [1])
Item Group
Biomarkers of tissue damage and repair
C0005516 (UMLS CUI-1)
C0010957 (UMLS CUI-2)
C1705181 (UMLS CUI-3)
Neurofilaments
Item
Neurofilament chains
text
C0027834 (UMLS CUI [1])
GFAP
Item
GFAP
text
C0017626 (UMLS CUI [1])
S100
Item
S100
text
C0027758 (UMLS CUI [1])
NAA
Item
NAA
text
C0067684 (UMLS CUI [1])
Nitric oxide products
Item
Nitric oxide products
text
C0028128 (UMLS CUI [1])
Pentosidine
Item
Pentosidine
text
C0070317 (UMLS CUI [1])
BDNF
Item
BDNF
text
C0107103 (UMLS CUI [1])
CNTF
Item
CNTF
text
C0207071 (UMLS CUI [1])
GDNF
Item
GDNF
text
C0207072 (UMLS CUI [1])
NGF
Item
NGF
text
C0027752 (UMLS CUI [1])
NT3
Item
NT3
text
C0083735 (UMLS CUI [1])
NT4
Item
NT4
text
C1623464 (UMLS CUI [1])
Item Group
Other potential biomarkers
C0005516 (UMLS CUI-1)
C0205394 (UMLS CUI-2)
Myxovirus resistance protein A
Item
Myxovirus resistance protein A
text
C3711733 (UMLS CUI [1])
Myoinositol
Item
Myoinositol
text
C0021547 (UMLS CUI [1])
Bri2-23
Item
Bri2-23
text
Fetuin-A
Item
Fetuin-A
text
C3178998 (UMLS CUI [1])
ILT3
Item
ILT3
text
C0539587 (UMLS CUI [1])
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