Outpatients | Parkinson Disease
Item
1. outpatients with idiopathic pd according to the uk parkinson's disease society brain bank clinical diagnosis criteria.
boolean
C0029921 (UMLS CUI [1])
C0030567 (UMLS CUI [2])
Age
Item
2. age 30 years to 80 years.
boolean
C0001779 (UMLS CUI [1])
Antiparkinson Agents Dose Stable
Item
3. stable dose of antiparkinsonian medication 4 weeks prior to study entry.
boolean
C0003405 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Unified Parkinson's Disease Rating Scale Questionnaire | Modified Hoehn and Yahr Scale score
Item
4. patients must score 18 or higher on the updrs scale and 1.0 to 2.5 on the modified hoehn and yahr scale.
boolean
C3639721 (UMLS CUI [1])
C4274318 (UMLS CUI [2])
Childbearing Potential Contraceptive methods
Item
5. women of child-bearing potential must use a reliable method of contraception.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Urinary Incontinence Symptoms | Urination Quantity times/day | Incontinence Episode Quantity times/week
Item
6. must be experiencing symptoms of urinary incontinence (voiding 8 or more times/day or episodes of incontinence 5 or more times per week).
boolean
C0042024 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C0042034 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0439511 (UMLS CUI [2,3])
C0042024 (UMLS CUI [3,1])
C0332189 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
C0456698 (UMLS CUI [3,4])
Prostate specific antigen normal | Urodynamic studies normal
Item
7. patients must have evidence of normal psa and urodynamic tests within the last 12 months.
boolean
C0580554 (UMLS CUI [1])
C0580523 (UMLS CUI [2])
Renal clearance Physical Examination Urologist | Renal clearance Physical Examination Internist
Item
8. clearance from the patient's urologist or internist who has examined the patient within the last 12-months.
boolean
C0699829 (UMLS CUI [1,1])
C0031809 (UMLS CUI [1,2])
C0260314 (UMLS CUI [1,3])
C0699829 (UMLS CUI [2,1])
C0031809 (UMLS CUI [2,2])
C0278602 (UMLS CUI [2,3])
Illness Study Subject Participation Status Excluded
Item
1. any illness that in the investigator's opinion preclude participation in this study.
boolean
C0221423 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C2828389 (UMLS CUI [1,3])
Pregnancy | Breast Feeding
Item
2. pregnancy or lactation.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Study Subject Participation Status
Item
3. concurrent participation in another clinical study.
boolean
C2348568 (UMLS CUI [1])
Dementia Preventing Informed Consent | Mental disorders Preventing Informed Consent | Mini-mental state examination
Item
4. dementia or other psychiatric illness that prevents the patient from giving informed consent (mini mental status exam score less than 24).
boolean
C0497327 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C0004936 (UMLS CUI [2,1])
C1292733 (UMLS CUI [2,2])
C0021430 (UMLS CUI [2,3])
C0451306 (UMLS CUI [3])
Legal capacity Lacking | Legal capacity Limited
Item
5. legal incapacity or limited legal capacity.
boolean
C0683673 (UMLS CUI [1,1])
C0332268 (UMLS CUI [1,2])
C0683673 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
Kidney Disease Severe | Blood urea nitrogen increased
Item
6. presence of severe renal disease (bun 50% greater than normal).
boolean
C0022658 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0151539 (UMLS CUI [2])
Hepatic impairment Major
Item
7. presence of major hepatic impairment.
boolean
C0948807 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
Ketoconazole Antifungal | CYP3A4 Inhibitors
Item
8. currently taking ketaconazole (anti-fungal) or any cyp3a4 inhibitor.
boolean
C0022625 (UMLS CUI [1,1])
C0003308 (UMLS CUI [1,2])
C3850053 (UMLS CUI [2])
Bladder outflow obstruction | Gastrointestinal obstruction
Item
9. any history of bladder outflow obstruction or gastrointestinal obstructive disorders.
boolean
C0403654 (UMLS CUI [1])
C0236124 (UMLS CUI [2])
Angle Closure Glaucoma Controlled
Item
10. history of controlled narrow angle glaucoma.
boolean
C0017605 (UMLS CUI [1,1])
C2911690 (UMLS CUI [1,2])