Autologous hematopoietic stem cell transplant Status post | First Relapse
Item
first relapse after asct
boolean
C2193200 (UMLS CUI [1,1])
C0231290 (UMLS CUI [1,2])
C4054953 (UMLS CUI [2])
Myeloma Symptomatic
Item
symptomatic myeloma
boolean
C0026764 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
Stem cells CD34 positive Available | Stem cells Support
Item
more than 2,0 x 10^6 cd34+ stem cells / kg bodyweight in the freezer for stem cell support
boolean
C0038250 (UMLS CUI [1,1])
C0882849 (UMLS CUI [1,2])
C0470187 (UMLS CUI [1,3])
C0038250 (UMLS CUI [2,1])
C1521721 (UMLS CUI [2,2])
Informed Consent
Item
signed informed consent given prior to any study related activities have been performed
boolean
C0021430 (UMLS CUI [1])
Age
Item
age > 18 years
boolean
C0001779 (UMLS CUI [1])
Homologous Transplantation Scheduled
Item
allogeneic transplantation scheduled as a part of the treatment
boolean
C0040739 (UMLS CUI [1,1])
C0205539 (UMLS CUI [1,2])
Life Expectancy
Item
expected survival of less than one month.
boolean
C0023671 (UMLS CUI [1])
WHO performance status scale
Item
performance status (who) > 3
boolean
C1298650 (UMLS CUI [1])
Neuropathy CTCAE Grades | Neurologic Symptoms Interfere with Activities of Daily Living
Item
neuropathy > grade 3 (neurological symptoms interfering with adl)
boolean
C0442874 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
C0235031 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0001288 (UMLS CUI [2,3])
Non-secretory myeloma
Item
non-secreting myeloma
boolean
C0456845 (UMLS CUI [1])
Comorbidity | Bortezomib Inappropriate
Item
other concurrent disease making bortezomib treatment unsuitable
boolean
C0009488 (UMLS CUI [1])
C1176309 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
Childbearing Potential Pregnancy test positive
Item
positive pregnancy test (only applicable for women with childbearing potential)
boolean
C3831118 (UMLS CUI [1,1])
C0240802 (UMLS CUI [1,2])
Melphalan allergy | Melphalan allergy Suspected | Intolerance to Melphalan | Intolerance to Melphalan Suspected | Dexamethasone allergy | Dexamethasone allergy Suspected | Intolerance to Dexamethasone | Intolerance to Dexamethasone Suspected | Hypersensitivity Boron | Hypersensitivity Boron Suspected | Intolerance to Boron | Intolerance to Boron Suspected | Mannitol allergy | Mannitol allergy Suspected | Intolerance to Mannitol | Intolerance to Mannitol Suspected | Heparin allergy | Heparin allergy Suspected | Intolerance Heparin | Intolerance to Heparin Suspected | Indwelling Catheter Use of
Item
has known or suspected hypersensitivity or intolerance to melphalan, dexamethasone, boron, mannitol, or heparin, if an indwelling catheter is used
boolean
C0570673 (UMLS CUI [1])
C0570673 (UMLS CUI [2,1])
C0750491 (UMLS CUI [2,2])
C1744706 (UMLS CUI [3,1])
C0025241 (UMLS CUI [3,2])
C1744706 (UMLS CUI [4,1])
C0025241 (UMLS CUI [4,2])
C0750491 (UMLS CUI [4,3])
C0571611 (UMLS CUI [5])
C0571611 (UMLS CUI [6,1])
C0750491 (UMLS CUI [6,2])
C1744706 (UMLS CUI [7,1])
C0011777 (UMLS CUI [7,2])
C1744706 (UMLS CUI [8,1])
C0011777 (UMLS CUI [8,2])
C0750491 (UMLS CUI [8,3])
C0020517 (UMLS CUI [9,1])
C0006030 (UMLS CUI [9,2])
C0020517 (UMLS CUI [10,1])
C0006030 (UMLS CUI [10,2])
C0750491 (UMLS CUI [10,3])
C1744706 (UMLS CUI [11,1])
C0006030 (UMLS CUI [11,2])
C1744706 (UMLS CUI [12,1])
C0006030 (UMLS CUI [12,2])
C0750491 (UMLS CUI [12,3])
C0571922 (UMLS CUI [13])
C0571922 (UMLS CUI [14,1])
C0750491 (UMLS CUI [14,2])
C1744706 (UMLS CUI [15,1])
C0024730 (UMLS CUI [15,2])
C1744706 (UMLS CUI [16,1])
C0024730 (UMLS CUI [16,2])
C0750491 (UMLS CUI [16,3])
C0571776 (UMLS CUI [17])
C0571776 (UMLS CUI [18,1])
C0750491 (UMLS CUI [18,2])
C1744706 (UMLS CUI [19,1])
C0019134 (UMLS CUI [19,2])
C1744706 (UMLS CUI [20,1])
C0019134 (UMLS CUI [20,2])
C0750491 (UMLS CUI [20,3])
C0007439 (UMLS CUI [21,1])
C1524063 (UMLS CUI [21,2])
Cardiovascular Disease Uncontrolled | Cardiovascular Disease Severe | Myocardial Infarction | Heart failure New York Heart Association Classification | Angina Pectoris Uncontrolled | Disorder of pericardium | Cardiac amyloidosis
Item
uncontrolled or severe cardiovascular disease including myocardial infarction within 6 months of enrolment, new york heart association (nyha) class iii or iv heart failure (attachment 6, nyha classification of cardiac disease), uncontrolled angina, clinically significant pericardial disease, or cardiac amyloidosis
boolean
C0007222 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0007222 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0027051 (UMLS CUI [3])
C0018801 (UMLS CUI [4,1])
C1275491 (UMLS CUI [4,2])
C0002962 (UMLS CUI [5,1])
C0205318 (UMLS CUI [5,2])
C0265122 (UMLS CUI [6])
C0268407 (UMLS CUI [7])
Hypotension | Decreased Blood Pressure | Sitting systolic blood pressure | Sitting diastolic blood pressure
Item
history of hypotension or has decreased blood pressure (sitting systolic blood pressure [sbp] <= 100 mmhg and/or sitting diastolic blood pressure [dbp] <= 60 mmhg)
boolean
C0020649 (UMLS CUI [1])
C2917141 (UMLS CUI [2])
C1319893 (UMLS CUI [3])
C1319894 (UMLS CUI [4])
Illness Serious Interferes with Study Subject Participation Status | Serious mental illness Interferes with Study Subject Participation Status
Item
serious medical or psychiatric illness likely to interfere with participation in this clinical study
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0521102 (UMLS CUI [1,3])
C2348568 (UMLS CUI [1,4])
C3841614 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C2348568 (UMLS CUI [2,3])
Investigational New Drugs | Investigational Medical Device
Item
have received an experimental drug or used an experimental medical device within 4 weeks prior to inclusion into the study
boolean
C0013230 (UMLS CUI [1])
C2346570 (UMLS CUI [2])