Major Depressive Disorder Unipolar Hamilton depression rating scale (HDRS) | Psychotic feature Absent
Item
diagnosis: major depression, unipolar without psychotic features (by dsm-iv criteria)-severity of depression: a 24-item hdrs above 19 at screening and at baseline -
boolean
C1269683 (UMLS CUI [1,1])
C0041696 (UMLS CUI [1,2])
C2021166 (UMLS CUI [1,3])
C0743076 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Executive dysfunction Level | Stroop Test
Item
level of executive dysfunction: two strata within each age stratum: stroop color-word scores - one half of the sample < 26, one of half ≥ 26.
boolean
C2748208 (UMLS CUI [1,1])
C0441889 (UMLS CUI [1,2])
C2718024 (UMLS CUI [2])
Informed Consent
Item
capacity to provide informed consent.
boolean
C0021430 (UMLS CUI [1])
High suicide risk | Suicide attempt Intent | Suicide attempt Planned
Item
high suicide risk, i.e. intent or plan to attempt suicide in near future
boolean
C1271074 (UMLS CUI [1])
C0038663 (UMLS CUI [2,1])
C1283828 (UMLS CUI [2,2])
C0038663 (UMLS CUI [3,1])
C1301732 (UMLS CUI [3,2])
Axis I diagnosis | Major Depressive Disorder Unipolar | Phobia, Specific | Substance Use Disorders
Item
presence of any current axis i psychiatric disorder (other than unipolar major depression or specific phobias) including substance abuse (those with a history of substance abuse must be abstinent for at least 3 months prior to entry)
boolean
C0270287 (UMLS CUI [1])
C1269683 (UMLS CUI [2,1])
C0041696 (UMLS CUI [2,2])
C0236801 (UMLS CUI [3])
C0038586 (UMLS CUI [4])
Axis II diagnosis | Antisocial Personality Disorder | Mental Retardation | Pervasive Development Disorder
Item
axis ii diagnosis of antisocial personality disorder, mental retardation and pervasive developmental disorder (dsm-iv)
boolean
C0270288 (UMLS CUI [1])
C0003431 (UMLS CUI [2])
C0025362 (UMLS CUI [3])
C0524528 (UMLS CUI [4])
Mental disorders | Depression, psychotic | Psychotic Disorder Primary | Bipolar Disorder | Hypomania
Item
history of psychiatric disorders such as psychotic depression, primary psychotic disorder, or bipolar spectrum disorder (bipolar disorder and hypomania are exclusions)
boolean
C0004936 (UMLS CUI [1])
C0743072 (UMLS CUI [2])
C0033975 (UMLS CUI [3,1])
C0205225 (UMLS CUI [3,2])
C0005586 (UMLS CUI [4])
C0241934 (UMLS CUI [5])
Cognition | Mini-mental state examination | Dementia
Item
cognition: mmse scores below 24 or diagnosis of dementia by dsm-iv
boolean
C0009240 (UMLS CUI [1])
C0451306 (UMLS CUI [2])
C0497327 (UMLS CUI [3])
Illness | Illness Severe | Delirium | Neoplasm Metastasis | Decompensated cardiac failure | Liver Failure Decompensated | Kidney Failure Decompensated | Major surgery | Cerebrovascular accident | Myocardial Infarction | Pharmaceutical Preparations Causing Depressive disorder | Reserpine | Methyldopa | Steroids | Sympathomimetics Withdrawal
Item
acute or severe medical illness, i.e., delirium, metastatic cancer, decompensated cardiac, liver or kidney failure, major surgery, stroke or myocardial infarction during the three months prior to entry; or drugs known to cause depression, e.g., reserpine, alpha-methyl-dopa, steroids, sympathomimetics withdrawal
boolean
C0221423 (UMLS CUI [1])
C0221423 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0011206 (UMLS CUI [3])
C0027627 (UMLS CUI [4])
C0581377 (UMLS CUI [5])
C0085605 (UMLS CUI [6,1])
C0205434 (UMLS CUI [6,2])
C0035078 (UMLS CUI [7,1])
C0205434 (UMLS CUI [7,2])
C0679637 (UMLS CUI [8])
C0038454 (UMLS CUI [9])
C0027051 (UMLS CUI [10])
C0013227 (UMLS CUI [11,1])
C0678227 (UMLS CUI [11,2])
C0011581 (UMLS CUI [11,3])
C0035179 (UMLS CUI [12])
C0025741 (UMLS CUI [13])
C0038317 (UMLS CUI [14])
C0039052 (UMLS CUI [15,1])
C2349954 (UMLS CUI [15,2])
Nervous system disorder | Parkinson Disease | Epilepsy Primary | Epilepsy Secondary | Neoplasms, Intracranial | Craniocerebral Trauma Severe | Neurodegenerative Disorders
Item
presence of a significant neurological disease such as parkinson's disease, primary or secondary seizure disorders, intracranial tumors, severe head trauma; neurodegenerative diseases i.e. ms
boolean
C0027765 (UMLS CUI [1])
C0030567 (UMLS CUI [2])
C0014544 (UMLS CUI [3,1])
C0205225 (UMLS CUI [3,2])
C0014544 (UMLS CUI [4,1])
C0175668 (UMLS CUI [4,2])
C1527390 (UMLS CUI [5])
C0018674 (UMLS CUI [6,1])
C0205082 (UMLS CUI [6,2])
C0524851 (UMLS CUI [7])
Escitalopram | Lexapro | Depressive episode Absent response to treatment
Item
history of failure to respond to escitalopram (lexapro) (20mg/day for 6 weeks or longer) during the current or previous depressive episodes
boolean
C1099456 (UMLS CUI [1])
C1170371 (UMLS CUI [2])
C0349217 (UMLS CUI [3,1])
C0438286 (UMLS CUI [3,2])
Intolerance to Escitalopram | Intolerance to Lexapro | Medical contraindication Escitalopram | Fluoxetine
Item
history of intolerance to escitalopram (lexapro) or use of concomitant drugs that may provide reason to believe that escitalopram is contraindicated. active treatment with fluoxetine at the time of screening
boolean
C1744706 (UMLS CUI [1,1])
C1099456 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C1170371 (UMLS CUI [2,2])
C1301624 (UMLS CUI [3,1])
C1099456 (UMLS CUI [3,2])
C0016365 (UMLS CUI [4])
Psychotropic Drugs Withdraw Unwilling | Psychotropic Drugs Withdraw Unable | Opiates Low dose | Opiates Dose Stable | Sedative hypnotics (non-benzodiazepines) | zolpidem | zaleplon | Eszopiclone | Diazepam Low dose | Diazepam Dose Stable | Anti-Anxiety Agents
Item
patients' unwillingness or inability to gradually withdraw all other psychotropic medications (except for the following: low and stable doses of opiates and non-benzodiazepine hypnotics (e.g. zolpidem (5 or 10 mg), zaleplon (5 or 10 mg), or eszopiclone (1 or 2 mg).low and stable doses of diazepam and other anxiolytics should be tapered at screening; inability to tolerate taper is not an exclusion criteria.
boolean
C0033978 (UMLS CUI [1,1])
C2349954 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
C0033978 (UMLS CUI [2,1])
C2349954 (UMLS CUI [2,2])
C1299582 (UMLS CUI [2,3])
C0376196 (UMLS CUI [3,1])
C0445550 (UMLS CUI [3,2])
C0376196 (UMLS CUI [4,1])
C0178602 (UMLS CUI [4,2])
C0205360 (UMLS CUI [4,3])
C3854290 (UMLS CUI [5])
C0078839 (UMLS CUI [6])
C0251504 (UMLS CUI [7])
C1436328 (UMLS CUI [8])
C0012010 (UMLS CUI [9,1])
C0445550 (UMLS CUI [9,2])
C0012010 (UMLS CUI [10,1])
C0178602 (UMLS CUI [10,2])
C0205360 (UMLS CUI [10,3])
C0040616 (UMLS CUI [11])
Performance of activities of daily living Unable
Item
inability to perform any of the adls (mai: adl subscale) even with assistance, e.g. walking with a cane is not an exclusion criterion
boolean
C1821398 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
Able to speak English Language
Item
inability to speak english
boolean
C0564215 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
Aphasia
Item
aphasia
boolean
C0003537 (UMLS CUI [1])