Multiple Myeloma | Leukemia, Myelocytic, Acute | MYELODYSPLASTIC SYNDROME | Acute lymphocytic leukemia | Lymphoma, Non-Hodgkin | Hodgkin Disease | Chronic Lymphocytic Leukemia | In complete remission | Therapeutic procedure Without Ablation | Therapeutic procedure With intensity Reduced
Item
1. patients with multiple myeloma (mm), acute myeloid leukemia (aml), myelodysplastic syndrome (mds), acute lymphoblastic leukemia (all), non-hodgkin's lymphoma (nhl), hodgkin's lymphoma (hl), or chronic lymphocytic leukemia (cll) in greater than first complete remission who are candidates for a non-ablative or reduced intensity conditioning regimen.
boolean
C0026764 (UMLS CUI [1])
C0023467 (UMLS CUI [2])
C3463824 (UMLS CUI [3])
C0023449 (UMLS CUI [4])
C0024305 (UMLS CUI [5])
C0019829 (UMLS CUI [6])
C0023434 (UMLS CUI [7])
C0677874 (UMLS CUI [8])
C0087111 (UMLS CUI [9,1])
C0332288 (UMLS CUI [9,2])
C0547070 (UMLS CUI [9,3])
C0087111 (UMLS CUI [10,1])
C0522510 (UMLS CUI [10,2])
C0392756 (UMLS CUI [10,3])
Age
Item
2. age up to 80 years.
boolean
C0001779 (UMLS CUI [1])
Donor Relative | Unrelated Donors | Histocompatibility crossmatch | HLA-A Antigens | HLA-B Antigens | HLA-C Antigens | HLA-DR locus | HLA-DQ Antigens | Peripheral blood stem cell | Bone marrow stem cell
Item
3. a related or unrelated donor who is hla-matched at hla, a, b, c, dr and dq loci is acceptable (i.e. 10/10 matched related or unrelated donor, matched with molecular high-resolution technique per current standard for the bmt program). donor must be willing to donate peripheral blood or bone marrow progenitor cells.
boolean
C0013018 (UMLS CUI [1,1])
C0080103 (UMLS CUI [1,2])
C3179133 (UMLS CUI [2])
C0549171 (UMLS CUI [3])
C0019728 (UMLS CUI [4])
C0019737 (UMLS CUI [5])
C0019751 (UMLS CUI [6])
C0221128 (UMLS CUI [7])
C0019761 (UMLS CUI [8])
C1518999 (UMLS CUI [9])
C1511246 (UMLS CUI [10])
Umbilical Cord Blood Unit Available | Nucleated cell Quantity | Histocompatibility crossmatch
Item
4. available cord blood unit must contain a minimum of 1.5 * 10^7 total nucleated cells per kg, and be at least a 4/6 hla match with patient.
boolean
C0162371 (UMLS CUI [1,1])
C0439148 (UMLS CUI [1,2])
C0470187 (UMLS CUI [1,3])
C1180059 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0549171 (UMLS CUI [3])
Zubrod Performance Status | Lansky Play-Performance Status
Item
5. zubrod ps less than or equal to 2 or lansky ps greater than or equal to 50%.
boolean
C3714786 (UMLS CUI [1])
C1522275 (UMLS CUI [2])
Left ventricular ejection fraction | Cardiac Arrhythmia Uncontrolled Absent | Heart Disease Symptomatic Absent
Item
6. left ventricular ejection fraction >40%. no uncontrolled arrhythmias or symptomatic heart disease.
boolean
C0428772 (UMLS CUI [1])
C0003811 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0018799 (UMLS CUI [3,1])
C0231220 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
FEV1 | Forced vital capacity | Carbon Monoxide Diffusing Capability Test
Item
7. forced expiratory volume in 1 second (fev1), forced vital capacity (fvc) and diffusion capacity (dlco) >40%.
boolean
C0748133 (UMLS CUI [1])
C1287681 (UMLS CUI [2])
C1516251 (UMLS CUI [3])
Creatinine measurement, serum | Serum total bilirubin measurement
Item
8. serum creatinine <2.0 mg/dl. serum bilirubin <3 * upper limit of normal, sgpt <4 *
boolean
C0201976 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
Alanine aminotransferase measurement
Item
upper limit of normal.
boolean
C0201836 (UMLS CUI [1])
CNS disorder
Item
1. patients with active cns disease
boolean
C0007682 (UMLS CUI [1])
Childbearing Potential Beta HCG positive | Postmenopausal state Absent | Female Sterilization Absent
Item
2. positive beta hcg in a woman with child bearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization.
boolean
C3831118 (UMLS CUI [1,1])
C0813152 (UMLS CUI [1,2])
C0232970 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0015787 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Illness Serious Interferes with Study Subject Participation Status | Mental disorder Serious Interferes with Study Subject Participation Status | Communicable Disease Uncontrolled | Cardiac Arrhythmia Uncontrolled | Event Ischemic | Psychotic Disorder Uncontrolled | Major Depressive Disorder | Manic Disorder
Item
3. serious medical or psychiatric illness likely to interfere with participation in this clinical study, including but not limited to active uncontrolled infection, uncontrolled cardiac arrhythmia or ischemic event, or uncontrolled psychosis, major depression, or mania.
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0521102 (UMLS CUI [1,3])
C2348568 (UMLS CUI [1,4])
C0004936 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C0521102 (UMLS CUI [2,3])
C2348568 (UMLS CUI [2,4])
C0009450 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C0003811 (UMLS CUI [4,1])
C0205318 (UMLS CUI [4,2])
C0441471 (UMLS CUI [5,1])
C0475224 (UMLS CUI [5,2])
C0033975 (UMLS CUI [6,1])
C0205318 (UMLS CUI [6,2])
C1269683 (UMLS CUI [7])
C0024713 (UMLS CUI [8])
Chronic Hepatitis Evidence of | Liver Cirrhosis Evidence of | HIV Infection Evidence of
Item
4. evidence of chronic, active hepatitis or cirrhosis, or hiv
boolean
C0019189 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
C0023890 (UMLS CUI [2,1])
C0332120 (UMLS CUI [2,2])
C0019693 (UMLS CUI [3,1])
C0332120 (UMLS CUI [3,2])