Multiple Myeloma
Item
subject was previously diagnosed with multiple myeloma based on standard diagnostic criteria, as follows.
boolean
C0026764 (UMLS CUI [1])
Criteria Main
Item
major criteria:
boolean
C0243161 (UMLS CUI [1,1])
C1542147 (UMLS CUI [1,2])
Plasmacytoma Biopsy tissue
Item
1. plasmacytomas on tissue biopsy.
boolean
C0032131 (UMLS CUI [1,1])
C3864006 (UMLS CUI [1,2])
BONE MARROW PLASMACYTOSIS Plasma Cells Percentage
Item
2. bone marrow plasmacytosis (> 30% plasma cells).
boolean
C0238803 (UMLS CUI [1,1])
C0032112 (UMLS CUI [1,2])
C0439165 (UMLS CUI [1,3])
Monoclonal immunoglobulin present | Serum electrophoresis Immunoglobulin G | Serum electrophoresis Immunoglobulin A | Free kappa light chain Excretion | Free lambda light chain Excretion | 24-hour urine protein electrophoresis
Item
3. monoclonal immunoglobulin spike on serum electrophoresis immunoglobulin g (igg) >3.5 g/dl or immunoglobulin a (iga) > 2.0 g/dl; kappa or lambda light chain excretion > 1 g/day on 24 hour urine protein electrophoresis.
boolean
C0860896 (UMLS CUI [1])
C0851095 (UMLS CUI [2,1])
C0020852 (UMLS CUI [2,2])
C0851095 (UMLS CUI [3,1])
C0020835 (UMLS CUI [3,2])
C0443743 (UMLS CUI [4,1])
C0221102 (UMLS CUI [4,2])
C0443744 (UMLS CUI [5,1])
C0221102 (UMLS CUI [5,2])
C2321676 (UMLS CUI [6])
Recurrent disease | Refractory Disease | Disease Progression | Second line treatment Patient need for | Third line treatment Patient need for
Item
patients must have relapsed or refractory disease (refractory is defined as progression during treatment or within 60 days after the completion of treatment) requiring 2nd or 3rd line therapy
boolean
C0277556 (UMLS CUI [1])
C1514815 (UMLS CUI [2])
C0242656 (UMLS CUI [3])
C1710038 (UMLS CUI [4,1])
C0686904 (UMLS CUI [4,2])
C2986605 (UMLS CUI [5,1])
C0686904 (UMLS CUI [5,2])
lenalidomide | Dexamethasone | Combined Modality Therapy Patients refractory
Item
patients refractory to a combination of lenalidomide and dexamethasone will not be eligible. patients may have received lenalidomide and/or dexamethasone
boolean
C1144149 (UMLS CUI [1])
C0011777 (UMLS CUI [2])
C0009429 (UMLS CUI [3,1])
C0030705 (UMLS CUI [3,2])
C0205269 (UMLS CUI [3,3])
Renal Insufficiency | Creatinine measurement, serum
Item
renal insufficiency (serum creatinine levels > 3 mg/dl)..
boolean
C1565489 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Allergic Reaction Perifosine Compound Similar | Allergic Reaction Miltefosine Compound Similar | Allergic Reaction Edelfosine Compound Similar
Item
history of allergic reactions attributed to compounds of similar chemical or biologic composition to perifosine (miltefosine or edelfosine).
boolean
C1527304 (UMLS CUI [1,1])
C0754570 (UMLS CUI [1,2])
C1706082 (UMLS CUI [1,3])
C2348205 (UMLS CUI [1,4])
C1527304 (UMLS CUI [2,1])
C0068006 (UMLS CUI [2,2])
C1706082 (UMLS CUI [2,3])
C2348205 (UMLS CUI [2,4])
C1527304 (UMLS CUI [3,1])
C0044549 (UMLS CUI [3,2])
C1706082 (UMLS CUI [3,3])
C2348205 (UMLS CUI [3,4])
Hypersensitivity Thalidomide
Item
known hypersensitivity to thalidomide
boolean
C0020517 (UMLS CUI [1,1])
C0039736 (UMLS CUI [1,2])