Age
Item
18 years of age or older
boolean
C0001779 (UMLS CUI [1])
Diffuse Large B-Cell Lymphoma CD20 positive Biopsy tissue | Mature (peripheral) B-cell neoplasm WHO tumor classification | Mature (peripheral) B-cell neoplasm REAL classification | Diffuse Large B-Cell Lymphoma | Mediastinal Large B-Cell Lymphoma | T-cell rich large B-cell lymphoma | Intravascular large B-cell lymphoma
Item
newly diagnosed histologically proven cd-20 positive diffuse large b- cell lymphoma by tissue biopsy, listed under peripheral b-cell neoplasm according to the who/real classification (diffuse large b-cell lymphoma, mediastinal large b-cell lymphoma, t-cell rich b-cell lymphoma, intravascular large b-cell lymphoma)
boolean
C0079744 (UMLS CUI [1,1])
C0882818 (UMLS CUI [1,2])
C3864006 (UMLS CUI [1,3])
C1532008 (UMLS CUI [2,1])
C1301142 (UMLS CUI [2,2])
C1532008 (UMLS CUI [3,1])
C1688661 (UMLS CUI [3,2])
C0079744 (UMLS CUI [4])
C1292754 (UMLS CUI [5])
C1321547 (UMLS CUI [6])
C0334660 (UMLS CUI [7])
Advanced disease Ann Arbor lymphoma staging system | Disease Ann Arbor lymphoma staging system | B-Symptoms | Involved-Field Radiation Therapy Unsuccessful | Chemotherapy Brief Inappropriate | Therapeutic radiology procedure Brief Inappropriate | Bulky Disease Single mass Diameter
Item
advanced stage disease defined as - patients with stage iii or stage iv disease; or patients with stage i or stage ii disease with one of the following additional criteria: b-symptoms, or disease that is not radio- encompassable within a single involved field, or not a candidate for brief chemotherapy and irradiation, or the presence of bulky disease (any single mass => 10 cm)
boolean
C0679246 (UMLS CUI [1,1])
C0432516 (UMLS CUI [1,2])
C0012634 (UMLS CUI [2,1])
C0432516 (UMLS CUI [2,2])
C1706867 (UMLS CUI [3])
C3826993 (UMLS CUI [4,1])
C1272705 (UMLS CUI [4,2])
C0392920 (UMLS CUI [5,1])
C1879313 (UMLS CUI [5,2])
C1548788 (UMLS CUI [5,3])
C1522449 (UMLS CUI [6,1])
C1879313 (UMLS CUI [6,2])
C1548788 (UMLS CUI [6,3])
C1511341 (UMLS CUI [7,1])
C1265601 (UMLS CUI [7,2])
C1301886 (UMLS CUI [7,3])
Patients untreated | Cycles Quantity R-CHOP regimen Dose
Item
previously untreated or treated with up to 3 cycles of standard dose 3- weekly r-chop chemotherapy prior to enrollment (i.e. patients may be enrolled prior to initiation of the fourth cycle of r-chop chemotherapy)
boolean
C0030705 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C1511572 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0393023 (UMLS CUI [2,3])
C0178602 (UMLS CUI [2,4])
ECOG performance status
Item
ecog performance status 0,1 or 2 at time of enrollment
boolean
C1520224 (UMLS CUI [1])
R-CHOP regimen | Progressive Disease Evidence Absent
Item
no evidence of progressive disease while on r-chop chemotherapy
boolean
C0393023 (UMLS CUI [1])
C1335499 (UMLS CUI [2,1])
C3887511 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Informed Consent
Item
the patient must sign the consent form prior to registration
boolean
C0021430 (UMLS CUI [1])
Lymphoproliferative Disorder | indolent lymphoma
Item
patients with a history of any other lymphoproliferative disorder, including prior history of indolent nhl
boolean
C0024314 (UMLS CUI [1])
C1334170 (UMLS CUI [2])
Malignant Neoplasms | Skin carcinoma Treated | Curative treatment Carcinoma in situ of uterine cervix
Item
patients with a history of prior or concurrent malignancies within 5 years of the current diagnosis, except adequately treated non- melanoma skin cancer, and curatively treated in-situ cancer of the cervix
boolean
C0006826 (UMLS CUI [1])
C0699893 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C1273390 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
HIV Infection
Item
known hiv infection
boolean
C0019693 (UMLS CUI [1])
Hepatitis B
Item
known hepatitis b virus infection
boolean
C0019163 (UMLS CUI [1])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods
Item
pregnancy or lactation. men and women of childbearing age must be using adequate contraception.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
Renal Insufficiency | Creatinine measurement, serum | Renal Insufficiency Due to Lymphoma
Item
significant renal insufficiency (serum creatinine > 200 mmol/l), unless due to lymphoma
boolean
C1565489 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
C1565489 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C0024299 (UMLS CUI [3,3])
Hepatic Insufficiency | Serum total bilirubin measurement | Hepatic Insufficiency Due to Lymphoma
Item
significant hepatic insufficiency (serum total bilirubin > 30 mmol/l), unless due to lymphoma
boolean
C1306571 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C1306571 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C0024299 (UMLS CUI [3,3])
Contraindication cardiac Doxorubicin | Heart Contractility Echocardiography abnormal | Heart Diseases | Ejection fraction normal Age Related
Item
cardiac contraindication to doxorubicin therapy (e.g. abnormal contractility on echocardiography). if history of cardiac disease, ejection fraction must be within normal limits for age.
boolean
C1301624 (UMLS CUI [1,1])
C0018787 (UMLS CUI [1,2])
C0013089 (UMLS CUI [1,3])
C1258017 (UMLS CUI [2,1])
C0476369 (UMLS CUI [2,2])
C0018799 (UMLS CUI [3])
C1535947 (UMLS CUI [4,1])
C0001779 (UMLS CUI [4,2])
C0439849 (UMLS CUI [4,3])
Contraindication Neurologic Vincristine | Peripheral Neuropathy
Item
neurologic contraindication to vincristine (e.g. peripheral neuropathy)
boolean
C1301624 (UMLS CUI [1,1])
C0205494 (UMLS CUI [1,2])
C0042679 (UMLS CUI [1,3])
C0031117 (UMLS CUI [2])
Absolute neutrophil count | Absolute neutrophil count Due to Lymphoma involves bone marrow | Absolute neutrophil count Due to R-CHOP regimen
Item
absolute neutrophil count <1.5 x 109/l (unless due to bone marrow involvement with lymphoma or due to initiation of r-chop chemotherapy)
boolean
C0948762 (UMLS CUI [1])
C0948762 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C1301440 (UMLS CUI [2,3])
C0948762 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C0393023 (UMLS CUI [3,3])
Platelet Count measurement | Platelet count Due to Splenomegaly | Platelet count Due to Lymphoma involves bone marrow | Platelet count Due to R-CHOP regimen
Item
platelet count < 100 x 109/l (unless due to splenomegaly, bone marrow involvement with lymphoma or due to initiation of r-chop chemotherapy)
boolean
C0032181 (UMLS CUI [1])
C1287267 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0038002 (UMLS CUI [2,3])
C1287267 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C1301440 (UMLS CUI [3,3])
C1287267 (UMLS CUI [4,1])
C0678226 (UMLS CUI [4,2])
C0393023 (UMLS CUI [4,3])
Sepsis Evidence of
Item
evidence of active systemic infection
boolean
C0243026 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
Medical condition compromises Therapeutic procedure | Medical condition Increasing Toxicity | Medical condition Impairing Assessment
Item
any medical condition that in the opinion of the investigator would compromise treatment delivery, add toxicity or impair assessment
boolean
C3843040 (UMLS CUI [1,1])
C2945640 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C0442808 (UMLS CUI [2,2])
C0600688 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C0221099 (UMLS CUI [3,2])
C1516048 (UMLS CUI [3,3])