Gender | Age
Item
1. female patients older than 15 years and younger than 46 years.
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Breast Carcinoma Primary TNM clinical staging
Item
2. primary breast cancer (stage i, ii, or iii).
boolean
C0678222 (UMLS CUI [1,1])
C0205225 (UMLS CUI [1,2])
C3258246 (UMLS CUI [1,3])
Invasive carcinoma of breast
Item
3. pathologically confirmed invasive breast carcinoma.
boolean
C0853879 (UMLS CUI [1])
Hormone Receptor Status Negative | Estrogen Receptor Staining Method Negative for tumor cells | Progesterone Receptor Staining Method Negative for tumor cells | Malignant Neoplasms Cytosol Ligand Binding Immunoassay | Malignant Neoplasms Cytosol Enzyme-Linked Immunosorbent Assay
Item
4. negative hormone-receptor status. (negative defined as er- and pr- staining in less than 10% of tumor cells, or tumors with less than or equal to 3 fm/mg cytosol protein on ligand-binding or enzyme-linked immunoassay).
boolean
C0019929 (UMLS CUI [1,1])
C0449438 (UMLS CUI [1,2])
C1513916 (UMLS CUI [1,3])
C4055053 (UMLS CUI [2,1])
C0332654 (UMLS CUI [2,2])
C4054151 (UMLS CUI [3,1])
C0332654 (UMLS CUI [3,2])
C0006826 (UMLS CUI [4,1])
C1383501 (UMLS CUI [4,2])
C1517880 (UMLS CUI [4,3])
C0020980 (UMLS CUI [4,4])
C0006826 (UMLS CUI [5,1])
C1383501 (UMLS CUI [5,2])
C0014441 (UMLS CUI [5,3])
Premenopausal state | Chemotherapy
Item
5. premenopausal, verified before chemotherapy is begun as satisfying both:
boolean
C0232969 (UMLS CUI [1])
C0392920 (UMLS CUI [2])
Vaginal Hemorrhage Cyclic
Item
cyclic vaginal bleeding.
boolean
C2979982 (UMLS CUI [1,1])
C0439596 (UMLS CUI [1,2])
Follicle stimulating hormone measurement | Contraceptives, Oral | Normal menstruation | Premenopausal state
Item
follicle-stimulating hormone (fsh) is less than or equal to 15 iu/l. if patients are taking oral contraceptives, fsh must be measured 1-2 weeks after discontinuation. if fsh is greater than 15 and the patient has regular menses, gynecologic consultation will be required for a decision on premenopausal status.
boolean
C0202022 (UMLS CUI [1])
C0009905 (UMLS CUI [2])
C0559892 (UMLS CUI [3])
C0232969 (UMLS CUI [4])
Neoadjuvant Chemotherapy Breast Carcinoma Primary | Adjuvant Chemotherapy Breast Carcinoma Primary
Item
6. candidates for neoadjuvant and/or adjuvant chemotherapy for primary breast cancer.
boolean
C0600558 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
C0678222 (UMLS CUI [1,3])
C0205225 (UMLS CUI [1,4])
C0085533 (UMLS CUI [2,1])
C0678222 (UMLS CUI [2,2])
C0205225 (UMLS CUI [2,3])
Chemotherapy cycle Quantity
Item
7. treatment with at least four (4) cycles of chemotherapy as planned.
boolean
C1302181 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Zubrod Performance Status
Item
8. zubrod performance score of 0 or 1.
boolean
C3714786 (UMLS CUI [1])
Ovarian function Preservation | Protocol Compliance
Item
9. must consent to preservation of their ovarian function and indicate their awareness of the investigational nature of this study, in keeping with institutional policy.
boolean
C0678879 (UMLS CUI [1,1])
C1514402 (UMLS CUI [1,2])
C0525058 (UMLS CUI [2])
Sexually active Barrier Contraception Willing
Item
10. willingness to use barrier contraception if sexually active.
boolean
C0241028 (UMLS CUI [1,1])
C0004764 (UMLS CUI [1,2])
C0600109 (UMLS CUI [1,3])
Pregnancy | Gender Pregnancy test negative | Injection of therapeutic agent
Item
1. pregnancy. women must have a negative serum pregnancy test before initiation of injection.
boolean
C0032961 (UMLS CUI [1])
C0079399 (UMLS CUI [2,1])
C0427780 (UMLS CUI [2,2])
C0021485 (UMLS CUI [3])
Hypersensitivity GnRH Analog
Item
2. hypersensitivity to any gnrh analog.
boolean
C0020517 (UMLS CUI [1,1])
C1518041 (UMLS CUI [1,2])
Systemic Chemotherapy
Item
3. previous receipt of systemic chemotherapy.
boolean
C1883256 (UMLS CUI [1])
cyclophosphamide/fluorouracil/methotrexate Chemotherapy cycle Quantity Neoadjuvant | cyclophosphamide/fluorouracil/methotrexate Chemotherapy cycle Quantity Adjuvant
Item
4. to receive at least 4 cycles of neoadjuvant and/or adjuvant chemotherapy with cmf.
boolean
C0950521 (UMLS CUI [1,1])
C1302181 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0600558 (UMLS CUI [1,4])
C0950521 (UMLS CUI [2,1])
C1302181 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C1522673 (UMLS CUI [2,4])
Breast Carcinoma TNM clinical staging
Item
5. stage iv breast cancer.
boolean
C0678222 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Prothrombin time assay | Partial prothrombin time | International Normalized Ratio
Item
6. prothrombin time (pt) and partial prothrombin time (ptt) with inr > 1.5
boolean
C0033707 (UMLS CUI [1])
C0853653 (UMLS CUI [2])
C0525032 (UMLS CUI [3])
Platelet Count measurement
Item
7. platelets < 50,000/mm^3
boolean
C0032181 (UMLS CUI [1])