Age
Item
1. men and women aged 18-80 years, inclusive.
boolean
C0001779 (UMLS CUI [1])
Outpatients Pharmaceutical Preparations Free of | Inpatient Major Depressive Disorder psychotic feature
Item
2. drug-free outpatients or inpatients meeting dsm-iv criteria for major depression with psychotic features.
boolean
C0029921 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C0332296 (UMLS CUI [1,3])
C0021562 (UMLS CUI [2,1])
C1269683 (UMLS CUI [2,2])
C0743076 (UMLS CUI [2,3])
Inpatient Washout Period | Selective Serotonin Reuptake Inhibitors | Abilify
Item
3. inpatients who undergo a 5-7 day washout period of their medication while concurrently beginning one of the approved ssri's and abilify.
boolean
C0021562 (UMLS CUI [1,1])
C1710661 (UMLS CUI [1,2])
C0360105 (UMLS CUI [2])
C1170019 (UMLS CUI [3])
Hamilton rating scale for depression
Item
4. ham-d-24 score > 16.
boolean
C0451203 (UMLS CUI [1])
Pregnancy | Childbearing Potential Contraceptive methods | Contraceptives, Oral
Item
1. pregnant women and women of child bearing potential not using a medically accepted means of contraception (oral contraceptives are allowed).
boolean
C0032961 (UMLS CUI [1])
C3831118 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
C0009905 (UMLS CUI [3])
Breast Feeding
Item
2. women who are breast-feeding.
boolean
C0006147 (UMLS CUI [1])
Major Depressive Disorder | psychotic feature | Psychotic Disorders
Item
3. patients meeting dsm-iv criteria for major depression without psychotic features, or psychosis without major depression at the screen visit.
boolean
C1269683 (UMLS CUI [1])
C0743076 (UMLS CUI [2])
C0033975 (UMLS CUI [3])
At risk for suicide Serious
Item
4. patients with serious suicidal risk.
boolean
C0563664 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
Epilepsy | Disease Unstable | Cardiovascular Diseases | Liver diseases | Kidney Diseases | Respiration Disorders | Endocrine System Diseases | nervous system disorder | Hematological Disease | Disease Significant Affecting central nervous system function
Item
5. patients with a history of seizure disorder; unstable physical disorders (cardiovascular, hepatic, renal, respiratory, endocrine, neurologic, or hematologic); or any physical disorder judged to significantly affect central nervous system function.
boolean
C0014544 (UMLS CUI [1])
C0012634 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0007222 (UMLS CUI [3])
C0023895 (UMLS CUI [4])
C0022658 (UMLS CUI [5])
C0035204 (UMLS CUI [6])
C0014130 (UMLS CUI [7])
C0027765 (UMLS CUI [8])
C0018939 (UMLS CUI [9])
C0012634 (UMLS CUI [10,1])
C0750502 (UMLS CUI [10,2])
C0392760 (UMLS CUI [10,3])
C0683212 (UMLS CUI [10,4])
Organic brain syndrome | Substance Use Disorders | Bipolar Disorder | Schizoaffective Disorder | Antisocial Personality Disorder
Item
6. patients meeting criteria for the following dsm-iv diagnoses: organic mental disorders; substance use disorders, including alcohol, active within the last 6 months; bipolar disorder; schizoaffective disorder; or antisocial personality disorder.
boolean
C0029221 (UMLS CUI [1])
C0038586 (UMLS CUI [2])
C0005586 (UMLS CUI [3])
C0036337 (UMLS CUI [4])
C0003431 (UMLS CUI [5])
Antidepressive Agents Disease Response | Antipsychotic Agents Disease Response | Mood stabilizing agent Disease Response | Washout Period supervision
Item
7. patients who are currently taking an antidepressant, antipsychotic, or mood stabilizing drug and who are responding to one or all of these medications. if patients are not responding to these medications, they may go through a washout period of at least one week under the supervision of a study doctor before entering into this study.
boolean
C0003289 (UMLS CUI [1,1])
C1704632 (UMLS CUI [1,2])
C0040615 (UMLS CUI [2,1])
C1704632 (UMLS CUI [2,2])
C1533054 (UMLS CUI [3,1])
C1704632 (UMLS CUI [3,2])
C1710661 (UMLS CUI [4,1])
C0814286 (UMLS CUI [4,2])
Informed Consent Unable
Item
8. patients who are not able to read and understand the consent form, or who are not capable of understanding or giving informed consent to the procedures of the study
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])