Gender | Age
Item
1. women aged ³70 years
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Early-Stage Breast Carcinoma | Adjuvant Chemotherapy Recommended
Item
2. histologic diagnosis of early breast cancer for which the treating physician considers adjuvant chemotherapy to be beneficial. recommended situations are for example:
boolean
C2986665 (UMLS CUI [1])
C0085533 (UMLS CUI [2,1])
C0034866 (UMLS CUI [2,2])
Hormone Therapy Absent response to treatment | Estrogen receptor negative | progesterone receptor negative | TNM clinical staging
Item
endocrine non responsive (er- and pgr -) and pt>1 cm, any t if n+ or
boolean
C0279025 (UMLS CUI [1,1])
C0438286 (UMLS CUI [1,2])
C0279756 (UMLS CUI [2])
C0279766 (UMLS CUI [3])
C3258246 (UMLS CUI [4])
Hormone Therapy Response to treatment doubtful | Estrogen receptor negative | progesterone receptor negative | Estrogen Receptors Poor | Progesterone Receptors Poor | percent positive cells | Immunohistochemistry | risk factors | TNM clinical staging | ERBB2 gene Positive
Item
endocrine responsiveness doubtful (er and/or pgr- or poor [3 to-5 according to harvey score (12) or £ 30% of positive cells by immunohistochemistry) and other risk factors (pt³2 cm or n+ or g3 or her-2/neu positive, etc.) or
boolean
C0279025 (UMLS CUI [1,1])
C0521982 (UMLS CUI [1,2])
C0750558 (UMLS CUI [1,3])
C0279756 (UMLS CUI [2])
C0279766 (UMLS CUI [3])
C0034804 (UMLS CUI [4,1])
C0542537 (UMLS CUI [4,2])
C0034833 (UMLS CUI [5,1])
C0542537 (UMLS CUI [5,2])
C0439178 (UMLS CUI [6])
C0021044 (UMLS CUI [7])
C0035648 (UMLS CUI [8])
C3258246 (UMLS CUI [9])
C0242957 (UMLS CUI [10,1])
C1514241 (UMLS CUI [10,2])
Hormone Therapy Response to treatment | Estrogen receptor positive | progesterone receptor positive | percent positive cells | Immunohistochemistry | risk factors Quantity | TNM clinical staging | ERBB2 gene Positive
Item
endocrine responsive (er and pgr > 5 according to harvey score or > 30% of positive cells by immunohistochemistry) and at least two risk factors (pt³ 2 cm, n+, g3, her-2/neu positive, etc.) or
boolean
C0279025 (UMLS CUI [1,1])
C0521982 (UMLS CUI [1,2])
C0279754 (UMLS CUI [2])
C0279759 (UMLS CUI [3])
C0439178 (UMLS CUI [4])
C0021044 (UMLS CUI [5])
C0035648 (UMLS CUI [6,1])
C1265611 (UMLS CUI [6,2])
C3258246 (UMLS CUI [7])
C0242957 (UMLS CUI [8,1])
C1514241 (UMLS CUI [8,2])
TNM clinical staging | Estrogen Receptor Any | Progesterone Receptor Any
Item
very high risk (n>3) any er/pgr.
boolean
C3258246 (UMLS CUI [1])
C0034804 (UMLS CUI [2,1])
C1552551 (UMLS CUI [2,2])
C0034833 (UMLS CUI [3,1])
C1552551 (UMLS CUI [3,2])
ECOG performance status
Item
3. ecog performance status £ 1
boolean
C1520224 (UMLS CUI [1])
Chemotherapy Exposure to | Neoadjuvant Therapy Chemotherapy
Item
4. no previous exposition to chemotherapy in the neoadjuvant setting
boolean
C3665472 (UMLS CUI [1,1])
C0332157 (UMLS CUI [1,2])
C0600558 (UMLS CUI [2,1])
C3665472 (UMLS CUI [2,2])
organ function
Item
5. adequate organ function including:
boolean
C0678852 (UMLS CUI [1])
Absolute neutrophil count
Item
1. neutrophils ³ 1.5 x 109 /l
boolean
C0948762 (UMLS CUI [1])
Platelet Count measurement
Item
2. platelets ³100 x 109 / l
boolean
C0032181 (UMLS CUI [1])
Serum total bilirubin measurement
Item
3. bilirubin < 1.25 x upper normal limit for the institution
boolean
C1278039 (UMLS CUI [1])
Transaminases
Item
4. transaminases < 2.5 x upper normal limit for the institution
boolean
C0002594 (UMLS CUI [1])
Estimation of creatinine clearance by Cockcroft-Gault formula
Item
5. calculated creatinine clearance of > 30ml/min (using the crockoft and gault formula)
boolean
C2711451 (UMLS CUI [1])
Absence
Item
6. absence of
boolean
C0332197 (UMLS CUI [1])
Ventricular arrhythmia Symptomatic
Item
symptomatic ventricular arrhythmias;
boolean
C0085612 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
Congestive heart failure Clinical Significance
Item
clinically significant congestive heart failure;
boolean
C0018802 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
Myocardial Infarction Evidence Clinical | Myocardial Infarction Evidence Electrocardiography
Item
clinical and/or ecg evidence of myocardial infarction within the last 12 months;
boolean
C0027051 (UMLS CUI [1,1])
C3887511 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
C0027051 (UMLS CUI [2,1])
C3887511 (UMLS CUI [2,2])
C1623258 (UMLS CUI [2,3])
Coronary Artery Disease Requirement Pharmaceutical Preparations
Item
coronary artery disease requiring medication.
boolean
C1956346 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0013227 (UMLS CUI [1,3])
Condition Compliance behavior Limited | Comorbidity Compliance behavior Limited
Item
6. absence of any psychological, familial or sociological condition or comorbidities that may affect compliance
boolean
C0348080 (UMLS CUI [1,1])
C1321605 (UMLS CUI [1,2])
C0439801 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C1321605 (UMLS CUI [2,2])
C0439801 (UMLS CUI [2,3])
Informed Consent
Item
7. written informed consent obtained according to local ethics committee guidelines -
boolean
C0021430 (UMLS CUI [1])