American | Diabetes Mellitus, Non-Insulin-Dependent | Fasting blood glucose measurement Quantity | Random blood glucose measurement Associated with Symptoms | Oral Glucose Tolerance Test
Item
meets americans with disabilities act (ada) criteria for t2dm; if newly diagnosed, must have fasting blood glucose greater than 126 mg/dl on two occasions, a random blood glucose greater than 200 mg/dl with symptoms, or a diagnostic oral glucose tolerance test
boolean
C0596070 (UMLS CUI [1])
C0011860 (UMLS CUI [2])
C0428568 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0428567 (UMLS CUI [4,1])
C0332281 (UMLS CUI [4,2])
C1457887 (UMLS CUI [4,3])
C0029161 (UMLS CUI [5])
Body Weight
Item
weight of less than 350 pounds
boolean
C0005910 (UMLS CUI [1])
Glycosylated hemoglobin A | Metformin Quantity per day | Sulfonylurea | Glipizide | alpha-Glucosidase Inhibitors
Item
hemoglobin a1c of equal to or less than 7.5% at study entry or willing to go on one of the following therapies to achieve necessary percentage: metformin monotherapy greater than 1000 mg daily for at least 30 days or metformin greater than 1000 mg daily plus any combination of sulfonylurea, glipizide, or alpha-glucosidase inhibitor
boolean
C0019018 (UMLS CUI [1])
C0025598 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0439505 (UMLS CUI [2,3])
C0038766 (UMLS CUI [3])
C0017642 (UMLS CUI [4])
C1299007 (UMLS CUI [5])
Blood Pressure
Item
blood pressure less than 140/90 mm hg at study entry
boolean
C0005823 (UMLS CUI [1])
Serum LDL cholesterol measurement | Lipid-lowering therapy Stable
Item
ldl level less than 130 mg/dl if on stable lipid lowering regimen
boolean
C0428474 (UMLS CUI [1])
C0585943 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
stress test echocardiogram at rest | Echocardiography, Stress | Treadmill Test | Dobutamine measurement
Item
willing to undergo normal rest/stress (treadmill or dobutamine) echocardiogram
boolean
C2035956 (UMLS CUI [1])
C0920208 (UMLS CUI [2])
C0087110 (UMLS CUI [3])
C1266511 (UMLS CUI [4])
Thyroid hormone replacement therapy | Thyroid preparations Dose Stable | Thyroid function tests normal
Item
if currently taking thyroid replacement therapy, must be on a stable dose of thyroid replacement and must have a thyroid function blood test that is in the normal range
boolean
C2242640 (UMLS CUI [1])
C0279175 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
C0729749 (UMLS CUI [3])
Contraceptive methods Willing
Item
willing to use an effective form of birth control throughout the study
boolean
C0700589 (UMLS CUI [1,1])
C0600109 (UMLS CUI [1,2])
Insulin regime | Thiazolidinediones
Item
received therapy with an insulin sensitizer of the thiazolidinedione class within 6 months prior to study entry
boolean
C0557978 (UMLS CUI [1])
C1257987 (UMLS CUI [2])
Insulin regime Duration of treatment
Item
required insulin therapy for more than 2 weeks in the year prior to study entry
boolean
C0557978 (UMLS CUI [1,1])
C0444921 (UMLS CUI [1,2])
Angina Pectoris | Myocardial Infarction | Coronary Artery Bypass Surgery | Cerebrovascular accident | Congestive heart failure | Peripheral Vascular Disease
Item
history of angina, heart attack, coronary artery bypass grafting (cabg), stroke, congestive heart failure (chf), or peripheral vascular disease (pvd)
boolean
C0002962 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C0010055 (UMLS CUI [3])
C0038454 (UMLS CUI [4])
C0018802 (UMLS CUI [5])
C0085096 (UMLS CUI [6])
Coronary Artery Disease | Residual Lesion Percentage
Item
known coronary artery disease (cad) with residual lesions of greater than 50%
boolean
C1956346 (UMLS CUI [1])
C0221198 (UMLS CUI [2,1])
C1609982 (UMLS CUI [2,2])
C0439165 (UMLS CUI [2,3])
Tobacco use
Item
current smoker
boolean
C0543414 (UMLS CUI [1])
Adrenal Cortex Hormones | Adrenal Cortex Hormones Use of Expected
Item
use or expected use of corticosteroids in any form
boolean
C0001617 (UMLS CUI [1])
C0001617 (UMLS CUI [2,1])
C1524063 (UMLS CUI [2,2])
C1517001 (UMLS CUI [2,3])
Serum Triglyceride Measurement Sample Fasting
Item
serum triglycerides greater than 400 mg/dl on a fasting sample at study entry
boolean
C0542495 (UMLS CUI [1,1])
C0370003 (UMLS CUI [1,2])
C0015663 (UMLS CUI [1,3])
Medical contraindication Thiazolidinediones | Medical contraindication Metformin | Medical contraindication Pharmaceutical Preparations
Item
any contraindication to a thiazolidinedione (tzd) insulin sensitizer, metformin, or other drugs likely to be used during the study
boolean
C1301624 (UMLS CUI [1,1])
C1257987 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0025598 (UMLS CUI [2,2])
C1301624 (UMLS CUI [3,1])
C0013227 (UMLS CUI [3,2])
Liver disease | Liver Function Tests
Item
liver disease with liver function test (lft) greater than 2 times the upper limit of normal (uln)
boolean
C0023895 (UMLS CUI [1])
C0023901 (UMLS CUI [2])
Creatinine measurement, serum | Gender | Proteinuria | Urine dipstick test
Item
serum creatinine greater than 1.5 mg/dl for women and 1.6 mg/dl for men or greater than 2+ proteinuria on urine dipstick
boolean
C0201976 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
C0033687 (UMLS CUI [3])
C0430370 (UMLS CUI [4])