Adult | Age
Item
adults older than 21 years.
boolean
C0001675 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Study Subject Has
Item
subjects must either have:
boolean
C0681850 (UMLS CUI [1,1])
C3539897 (UMLS CUI [1,2])
Insulin Resistance | Fasting blood glucose measurement | Prothrombin time assay
Item
1. insulin resistance as defined by a fasting blood sugar of greater than 110mg/dl and less than 126 mg/dl and confirmed with the quicki test.
boolean
C0021655 (UMLS CUI [1])
C0428568 (UMLS CUI [2])
C0033707 (UMLS CUI [3])
Diabetes Mellitus, Non-Insulin-Dependent | Glycosylated hemoglobin A | fasting insulin level | Fasting blood glucose measurement | Antidiabetics
Item
2. or the diagnosis of t2dm with a hba1c less than 9%, a fasting insulin level of greater than 6 uiu/ml and a fasting blood glucose level of greater than 125 mg/dl if not on anti-diabetic therapy.
boolean
C0011860 (UMLS CUI [1])
C0019018 (UMLS CUI [2])
C2016107 (UMLS CUI [3])
C0428568 (UMLS CUI [4])
C0935929 (UMLS CUI [5])
Study Protocol Comprehension | Informed Consent
Item
subject understands protocol and provides written, informed consent
boolean
C2348563 (UMLS CUI [1,1])
C0162340 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2])
Capacity Treadmill Test Physical Exertion Maximal | Respiratory Exchange Ratio Peak level | treadmill stress test using oxygen uptake protocol
Item
patients must demonstrate the capacity for a near maximal to maximal effort on a treadmill as measured by exercise ventilatory threshold. this will be measured by achieving a peak respiratory exchange ratio greater than or equal to 1.00 during the initial and final peak vo2 exercise tests.
boolean
C1516240 (UMLS CUI [1,1])
C0087110 (UMLS CUI [1,2])
C0031807 (UMLS CUI [1,3])
C0205289 (UMLS CUI [1,4])
C4049826 (UMLS CUI [2,1])
C0444505 (UMLS CUI [2,2])
C2059721 (UMLS CUI [3])
Structural disorder of heart Significant | Hypertrophic Cardiomyopathy | Cardiomyopathy, Dilated | Heart valve disease | Echocardiography | Coronary heart disease Unstable
Item
significant structural heart disease (e.g. hypertrophic or dilated cardiomyopathy, valvular heart disease) as determined by echocardiography or unstable coronary disease within the last 3 months.
boolean
C1290384 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0007194 (UMLS CUI [2])
C0007193 (UMLS CUI [3])
C0018824 (UMLS CUI [4])
C0013516 (UMLS CUI [5])
C0010068 (UMLS CUI [6,1])
C0443343 (UMLS CUI [6,2])
Uncontrolled hypertension
Item
uncontrolled hypertension.
boolean
C1868885 (UMLS CUI [1])
Heart failure
Item
history of heart failure.
boolean
C0018801 (UMLS CUI [1])
Left ventricular ejection fraction | Electrocardiography
Item
left ventricular ejection fraction less than 55% as measured by screening echocardiogram.
boolean
C0428772 (UMLS CUI [1])
C1623258 (UMLS CUI [2])
Treadmill Test Unable Due to nervous system disorder | Treadmill Test Unable Due to orthopedic problem
Item
subject physically unable to perform treadmill exercise due to neurologic or orthopedic conditions.
boolean
C0087110 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C0027765 (UMLS CUI [1,4])
C0087110 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])
C0678226 (UMLS CUI [2,3])
C0029354 (UMLS CUI [2,4])
Diabetes Mellitus, Insulin-Dependent | Thiazolidinediones
Item
insulin-dependent diabetes mellitus or current use of thiazolidinediones
boolean
C0011854 (UMLS CUI [1])
C1257987 (UMLS CUI [2])
Adverse event Thiazolidinediones
Item
history of adverse events on thiazolidinedione therapy
boolean
C0877248 (UMLS CUI [1,1])
C1257987 (UMLS CUI [1,2])
Childbearing Potential Age Pregnancy test negative
Item
women of childbearing age unless recent pregnancy test is negative.
boolean
C3831118 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C0427780 (UMLS CUI [1,3])
Breast Feeding
Item
lactating women.
boolean
C0006147 (UMLS CUI [1])
Creatinine measurement, serum
Item
serum creatinine greater than 2.5 mg/dl
boolean
C0201976 (UMLS CUI [1])
Liver Transaminases increased
Item
liver transaminase levels greater than 2.5 x upper limit of normal
boolean
C0023884 (UMLS CUI [1,1])
C0438717 (UMLS CUI [1,2])
Malignant Neoplasms
Item
history of cancer in the last 5 years
boolean
C0006826 (UMLS CUI [1])
Therapeutic procedure Illness Associated with Stem cell transplant
Item
history of treatment for any illness with stem cell transplantation
boolean
C0087111 (UMLS CUI [1,1])
C0221423 (UMLS CUI [1,2])
C0332281 (UMLS CUI [1,3])
C1504389 (UMLS CUI [1,4])
Inflammatory disorder
Item
active inflammatory disease
boolean
C1290884 (UMLS CUI [1])
Study Subject Participation Status | Investigational New Drugs
Item
enrollment in a any drug studies within the last 30 days
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])