Groups Study Subject Quantity Handedness | Gender | Premenopausal | Pharmaceutical Preparations Therapy naive | Psychotropic Drugs | Fluoxetine | Unipolar Depression | Healthy | Depressive disorder | Age | Smoking Status | Medication stopped Due to Lack of Efficacy | Medication stopped Due to Patient Non-Compliance
Item
two groups of right-handed subjects, male or premenopausal female, who are drug-naive or who have not received psychotropic drugs for at least 3 weeks (8 weeks for fluoxetine), will be recruited for studies under this protocol: unipolar depressives and healthy controls individually matched to depressives by age, gender and smoking status. because effective treatment will not be discontinued for the purposes of this protocol, subjects in the patient groups will be identified who have never been treated for or who have discontinued medication due to lack of efficacy, noncompliance, physician order or other reason prior to study entry.
boolean
C0441833 (UMLS CUI [1,1])
C0681850 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0023114 (UMLS CUI [1,4])
C0079399 (UMLS CUI [2])
C0279752 (UMLS CUI [3])
C0013227 (UMLS CUI [4,1])
C0919936 (UMLS CUI [4,2])
C0033978 (UMLS CUI [5])
C0016365 (UMLS CUI [6])
C0041696 (UMLS CUI [7])
C3898900 (UMLS CUI [8])
C0011581 (UMLS CUI [9])
C0001779 (UMLS CUI [10])
C1519386 (UMLS CUI [11])
C1273478 (UMLS CUI [12,1])
C0678226 (UMLS CUI [12,2])
C0235828 (UMLS CUI [12,3])
C1273478 (UMLS CUI [13,1])
C0678226 (UMLS CUI [13,2])
C0376405 (UMLS CUI [13,3])
Clinical interview unstructured Psychiatrist | Structured Clinical Interview DSM-IV | family history of mental illness | Psychiatric interview of family of patient | Genetic studies
Item
the presence of inclusion and exclusion criteria will be established using both an unstructured clinical interview with a psychiatrist and the structure clinical interview for dsm-iv (scid). family history of mental illness will be obtained using the family interview of genetic studies.
boolean
C0199182 (UMLS CUI [1,1])
C0683960 (UMLS CUI [1,2])
C0033872 (UMLS CUI [1,3])
C0935589 (UMLS CUI [2,1])
C0220952 (UMLS CUI [2,2])
C2186268 (UMLS CUI [3])
C0204499 (UMLS CUI [4])
C2827447 (UMLS CUI [5])
ID.3
Item
subjects will be excluded if they have:
boolean
Feeling suicidal Serious | Suicidal behavior Serious
Item
serious suicidal ideation or behavior;
boolean
C0424000 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C1760428 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
Informed Consent Unable
Item
inability to provide informed consent;
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
Illness Affecting physiology | Illness Affecting Anatomy | nervous system disorder Affecting physiology | nervous system disorder Affecting Anatomy
Item
medical or neurological illnesses likely to affect physiology or anatomy;
boolean
C0221423 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0031843 (UMLS CUI [1,3])
C0221423 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C1384516 (UMLS CUI [2,3])
C0027765 (UMLS CUI [3,1])
C0392760 (UMLS CUI [3,2])
C0031843 (UMLS CUI [3,3])
C0027765 (UMLS CUI [4,1])
C0392760 (UMLS CUI [4,2])
C1384516 (UMLS CUI [4,3])
Substance Use Disorders | Substance Dependence Lifetime
Item
a history of drug or alcohol abuse within 1 year or a lifetime history of alcohol or drug dependence (dsm-iv criteria);
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2,1])
C4071830 (UMLS CUI [2,2])
Axis I diagnosis Before Major Depressive Disorder Onset
Item
current or past history of other axis i disorders that preceded the onset of mdd;
boolean
C0270287 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C1269683 (UMLS CUI [1,3])
C0332162 (UMLS CUI [1,4])
Pregnancy Pregnancy Test
Item
current pregnancy (documented by pregnancy testing prior to scanning);
boolean
C0032961 (UMLS CUI [1,1])
C0032976 (UMLS CUI [1,2])
Breast Feeding
Item
current breast feeding;
boolean
C0006147 (UMLS CUI [1])
Exclusion Criteria MRI General
Item
general mri exclusion criteria;
boolean
C0680251 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C0205246 (UMLS CUI [1,3])
Visual Impairment Interferes with Testing | Hearing problem Interferes with Testing
Item
vision and/or hearing problems severe enough to interfere with testing.
boolean
C3665347 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0039593 (UMLS CUI [1,3])
C0260662 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0039593 (UMLS CUI [2,3])
Pharmaceutical Preparations Exposure Affecting Cerebral Blood Flow | Pharmaceutical Preparations Exposure Affecting heart rate
Item
exposure within two weeks to medications likely to affect cerebral blood glow or heart rate.
boolean
C0013227 (UMLS CUI [1,1])
C0332157 (UMLS CUI [1,2])
C0392760 (UMLS CUI [1,3])
C0428714 (UMLS CUI [1,4])
C0013227 (UMLS CUI [2,1])
C0332157 (UMLS CUI [2,2])
C0392760 (UMLS CUI [2,3])
C0018810 (UMLS CUI [2,4])
Condition Preventing walk test
Item
any condition that may prevent the subject from performing the run/walk test, or
boolean
C0348080 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0430517 (UMLS CUI [1,3])
Abnormal menstrual cycle | Menstrual cycle phase Determinate Unsuccessful
Item
irregular menstrual cycles so that menstrual phase cannot be reliably determined, or
boolean
C0232933 (UMLS CUI [1])
C1818633 (UMLS CUI [2,1])
C0205259 (UMLS CUI [2,2])
C1272705 (UMLS CUI [2,3])
EKG finding Contraindication PET scan | EKG finding Contraindication Walk test | ecg non-sinus rhythm | Tachycardia Significant | ST segment elevation | ST segment depression | Electrocardiogram Q waves test | Cardiac Arrhythmia | ECG abnormal
Item
any ecg finding that would contraindicate pet scanning or run/walk testing (e.g. non-sinus rhythm, significant tachycardia, st segment elevation or depression, q waves) or arrhythmia that would obviate accurate calculation of hrv indices. cardiology consultation will be obtained for abnormal ecg findings unless it is unequivocally clear in the judgment of the study physician that such consultation is medically unnecessary.
boolean
C0438154 (UMLS CUI [1,1])
C1301624 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
C0438154 (UMLS CUI [2,1])
C1301624 (UMLS CUI [2,2])
C0430517 (UMLS CUI [2,3])
C3649284 (UMLS CUI [3])
C0039231 (UMLS CUI [4,1])
C0750502 (UMLS CUI [4,2])
C0520886 (UMLS CUI [5])
C0520887 (UMLS CUI [6])
C0429089 (UMLS CUI [7])
C0003811 (UMLS CUI [8])
C0522055 (UMLS CUI [9])
Age | Postmenopausal state | Perimenopausal state | Autonomic function Heterogeneity biological | Menstrual status Difference
Item
subjects who are beyond age 50 who are either postmenopausal or perimenopausal are excluded to reduce the biological heterogeneity in autonomic function which may be associated with difference in menstrual status.
boolean
C0001779 (UMLS CUI [1])
C0232970 (UMLS CUI [2])
C3839366 (UMLS CUI [3])
C0518003 (UMLS CUI [4,1])
C0019409 (UMLS CUI [4,2])
C0205460 (UMLS CUI [4,3])
C0369663 (UMLS CUI [5,1])
C1705242 (UMLS CUI [5,2])