Single major depressive episode Unipolar
Item
currently suffering from a major depressive episode (unipolar only)
boolean
C0024517 (UMLS CUI [1,1])
C0443340 (UMLS CUI [1,2])
Suicide attempt Past | Hamilton rating scale for depression | Planning suicide | Suicidal intent | Inpatient treatment
Item
history of a past suicide attempt or score greater than 2 on the hamilton depression rating scale (hdrs) item #3 (suicide) at in-person screening interview. patients with suicidal plan or intent will only be enrolled as inpatients if independent inpatient treatment team agrees.
boolean
C0038663 (UMLS CUI [1,1])
C1444637 (UMLS CUI [1,2])
C0451203 (UMLS CUI [2])
C0424001 (UMLS CUI [3])
C0582496 (UMLS CUI [4])
C0019993 (UMLS CUI [5])
Age | Mini-mental state examination
Item
patients 60 years of age and older must score at least 25 on mmse at screening.
boolean
C0001779 (UMLS CUI [1])
C0451306 (UMLS CUI [2])
Age | ECG normal
Item
patients 60 years of age and older must have a normal ecg within the past year.
boolean
C0001779 (UMLS CUI [1])
C0522054 (UMLS CUI [2])
Bipolar Disorder | Psychotic symptom | Bulimia | Anorexia | Purging | Selective Serotonin Reuptake Inhibitors | Bupropion | Indication Anxiety Disorders
Item
any of the following conditions: bipolar disorder; current psychotic symptoms; bulimia or anorexia that is current or within the past year, or current purging at least twice a week for three months; already taking selective serotonin reuptake inhibitors (ssris) or bupropion for other indications (such as anxiety disorders)
boolean
C0005586 (UMLS CUI [1])
C0871189 (UMLS CUI [2])
C0006370 (UMLS CUI [3])
C0003123 (UMLS CUI [4])
C0855227 (UMLS CUI [5])
C0360105 (UMLS CUI [6])
C0085208 (UMLS CUI [7])
C3146298 (UMLS CUI [8,1])
C0003469 (UMLS CUI [8,2])
Anxiety Disorder Primary | Panic Disorder | Anxiety Disorders General | Obsessive-Compulsive Disorder | Phobia, Social | Depressive disorder Secondary
Item
primary disorder is an anxiety disorder (e.g., panic disorder, general anxiety disorder, obsessive compulsive disorder, social anxiety disorder), with secondary depression
boolean
C0003469 (UMLS CUI [1,1])
C0205225 (UMLS CUI [1,2])
C0030319 (UMLS CUI [2])
C0003469 (UMLS CUI [3,1])
C0205246 (UMLS CUI [3,2])
C0028768 (UMLS CUI [4])
C0031572 (UMLS CUI [5])
C0011581 (UMLS CUI [6,1])
C0175668 (UMLS CUI [6,2])
Substance Dependence | Substance Use Disorders | Single major depressive episode
Item
drug or alcohol dependence within 6 months prior to study entry (current drug or alcohol abuse may be permitted if study officials determine that the abuse is of lesser importance than the major depressive episode)
boolean
C0038580 (UMLS CUI [1])
C0038586 (UMLS CUI [2])
C0024517 (UMLS CUI [3])
Systolic Pressure | Diastolic blood pressure
Item
systolic blood pressure greater than or equal to 140 mm hg or diastolic blood pressure greater than or equal to 90 mm hg
boolean
C0871470 (UMLS CUI [1])
C0428883 (UMLS CUI [2])
physical illness Significant Affecting Brain | physical illness Significant Affecting Serotonergic Neurons System | Hematological Disease | Lymphoma | Hypersplenism | Endocrine System Diseases | Kidney Failure | Severe chronic obstructive pulmonary disease | Autonomic neuropathy | Malignant Neoplasms
Item
significant active physical illness, particularly those that may affect the brain or serotonergic system (e.g., blood dyscrasias lymphomas, hypersplenism, endocrinopathies, kidney failure, severe chronic obstructive lung disease, autonomic neuropathies, active malignancy)
boolean
C0683323 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0392760 (UMLS CUI [1,3])
C0006104 (UMLS CUI [1,4])
C0683323 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
C0392760 (UMLS CUI [2,3])
C3178783 (UMLS CUI [2,4])
C0449913 (UMLS CUI [2,5])
C0018939 (UMLS CUI [3])
C0024299 (UMLS CUI [4])
C0020532 (UMLS CUI [5])
C0014130 (UMLS CUI [6])
C0035078 (UMLS CUI [7])
C0730607 (UMLS CUI [8])
C0259749 (UMLS CUI [9])
C0006826 (UMLS CUI [10])
Medical Problems
Item
active medical problems
boolean
C1254481 (UMLS CUI [1])
Antipsychotic Agents Patient need for
Item
requires antipsychotic medication
boolean
C0040615 (UMLS CUI [1,1])
C0686904 (UMLS CUI [1,2])
Hypomania | Manic Disorder During Antidepressive Agents Intake
Item
history of hypomania or mania while taking antidepressants
boolean
C0241934 (UMLS CUI [1])
C0024713 (UMLS CUI [2,1])
C0347984 (UMLS CUI [2,2])
C0003289 (UMLS CUI [2,3])
C1512806 (UMLS CUI [2,4])
Condition Unfavorable Use of Selective Serotonin Reuptake Inhibitors | Condition Unfavorable Use of Bupropion
Item
any condition that may make the use of an ssri or bupropion medically inadvisable
boolean
C0348080 (UMLS CUI [1,1])
C3640815 (UMLS CUI [1,2])
C1524063 (UMLS CUI [1,3])
C0360105 (UMLS CUI [1,4])
C0348080 (UMLS CUI [2,1])
C3640815 (UMLS CUI [2,2])
C1524063 (UMLS CUI [2,3])
C0085208 (UMLS CUI [2,4])
Zyban
Item
currently using zyban
boolean
C0751626 (UMLS CUI [1])
Selective Serotonin Reuptake Inhibitors Quantity Unresponsive to Treatment | Paroxetine Unresponsive to Treatment | Bupropion Unresponsive to Treatment
Item
failure to respond to adequate trials of three ssris, paroxetine, or bupropion within 2 years prior to study entry (failure to respond to therapeutic trial defined as at least 2/3 maximal daily dose [pdr] for at least 6 weeks)
boolean
C0360105 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0205269 (UMLS CUI [1,3])
C0070122 (UMLS CUI [2,1])
C0205269 (UMLS CUI [2,2])
C0085208 (UMLS CUI [3,1])
C0205269 (UMLS CUI [3,2])
Pregnancy | Breast Feeding | Pregnancy, Planned
Item
pregnant, breastfeeding, or plans to become pregnant during the course of study participation
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032992 (UMLS CUI [3])
Therapeutic procedure Effective | Antipsychotic Agents Adjunctive treatment Patient need for | Mood stabilizing drug Adjunctive treatment Patient need for | Antidepressive Agent Single Unresponsive to Treatment Probable
Item
currently on effective treatment, requires adjunctive antipsychotic or mood stabilizing medication, or is unlikely to respond to single agent treatment for depression
boolean
C0087111 (UMLS CUI [1,1])
C1280519 (UMLS CUI [1,2])
C0040615 (UMLS CUI [2,1])
C3858690 (UMLS CUI [2,2])
C0686904 (UMLS CUI [2,3])
C1276998 (UMLS CUI [3,1])
C3858690 (UMLS CUI [3,2])
C0686904 (UMLS CUI [3,3])
C0003289 (UMLS CUI [4,1])
C0205171 (UMLS CUI [4,2])
C0205269 (UMLS CUI [4,3])
C0033204 (UMLS CUI [4,4])
presence of metallic implant | Claustrophobia Excludes Magnetic Resonance Imaging
Item
patients with ferrous metal implants in their bodies, or a history of claustrophobia that precludes mri, will be excluded.
boolean
C3693688 (UMLS CUI [1])
C0008909 (UMLS CUI [2,1])
C0332196 (UMLS CUI [2,2])
C0024485 (UMLS CUI [2,3])
Accept Unlikely Delay Start Therapeutic procedure
Item
patients assessed as being unlikely to tolerate the maximum 2-week delay to start of treatment.
boolean
C1272684 (UMLS CUI [1,1])
C0750558 (UMLS CUI [1,2])
C0205421 (UMLS CUI [1,3])
C0439659 (UMLS CUI [1,4])
C0087111 (UMLS CUI [1,5])