Study Subject Participation Status | Informed Consent
Item
subject understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent
boolean
C2348568 (UMLS CUI [1])
C0021430 (UMLS CUI [2])
Asthma | Age
Item
male and female aged 18-60 years of age with a clinical diagnosis of asthma, as per:
boolean
C0004096 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Adrenergic beta-Agonists Reversibility FEV1
Item
beta-agonist reversibility of fev1>12%, or
boolean
C0001644 (UMLS CUI [1,1])
C0449261 (UMLS CUI [1,2])
C0748133 (UMLS CUI [1,3])
Methacholine FEV1 | inhaled steroids
Item
methacholine fev1 pc20 ≤ 8 mg/ml if not receiving ics or ≤ 16mg/ml if receiving an ics.
boolean
C0600370 (UMLS CUI [1,1])
C0748133 (UMLS CUI [1,2])
C2065041 (UMLS CUI [2])
Asthma | Maintenance Pharmaceutical Preparations
Item
subject has asthma and is taking regular maintenance medication for the past 12 months that includes:
boolean
C0004096 (UMLS CUI [1])
C0024501 (UMLS CUI [2,1])
C0013227 (UMLS CUI [2,2])
inhaled steroids
Item
inhaled corticosteroid (ics)
boolean
C2065041 (UMLS CUI [1])
Adrenergic beta-Agonists
Item
long-acting beta agonist (laba)
boolean
C0001644 (UMLS CUI [1])
Leukotriene Antagonists | Anti-Immunoglobulin E antibody
Item
other asthma medication such as leukotriene modifier, or anti-ige, are acceptable
boolean
C0595726 (UMLS CUI [1])
C0051978 (UMLS CUI [2])
FEV1 pre bronchodilator
Item
fev1 > 50%pred pre-bronchodilator
boolean
C0748133 (UMLS CUI [1,1])
C2599602 (UMLS CUI [1,2])
Bronchial thermoplasty | Therapeutic procedure Asthma
Item
subject assigned by the clinical team to receive bronchial thermoplasty as part of their asthma treatment plan
boolean
C3854686 (UMLS CUI [1])
C0087111 (UMLS CUI [2,1])
C0004096 (UMLS CUI [2,2])
Non-smoker | Former smoker Smoking cigarettes: ____ pack-years history
Item
subject is a non-smoker for 1 year or greater (if former smoker less than 10 pack years total smoking history).
boolean
C0337672 (UMLS CUI [1])
C0337671 (UMLS CUI [2,1])
C2230126 (UMLS CUI [2,2])
Ability Pulmonary function tests | Spirometry | FEV1
Item
subject able to perform reproducible pulmonary function testing (i.e., the 3 best acceptable spirograms have fev1 values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater.)
boolean
C0085732 (UMLS CUI [1,1])
C0024119 (UMLS CUI [1,2])
C0037981 (UMLS CUI [2])
C0748133 (UMLS CUI [3])
Other personal health Stable status
Item
subject is judged to be in otherwise stable health on the basis of medical history
boolean
C0205394 (UMLS CUI [1,1])
C0683314 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Disease Study Subject Participation Status Limited
Item
subject is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material
boolean
C0012634 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C0439801 (UMLS CUI [1,3])
Unable Spirometry | Unable Plethysmography
Item
subject is unable to perform spirometry or plethysmography maneuvers
boolean
C1299582 (UMLS CUI [1,1])
C0037981 (UMLS CUI [1,2])
C1299582 (UMLS CUI [2,1])
C0032221 (UMLS CUI [2,2])
Patient currently pregnant
Item
subject is pregnant
boolean
C0549206 (UMLS CUI [1])
Exacerbation of asthma | Respiratory Tract Infections
Item
recent (within 4 weeks of bl visit 1) or current asthma exacerbation and/or respiratory tract infection
boolean
C0349790 (UMLS CUI [1])
C0035243 (UMLS CUI [2])
Implants | Artificial cardiac pacemaker | Neurostimulator | Biogenic Stimulators | Insulin pump | Aneurysm clip | Bioprosthesis device | Limb Prosthesis | Foreign Bodies | Shunt Device | Staple, Surgical | Surgical Clips | Metallic suture
Item
subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants.) (at the discretion of the mri technologist/3t manager)
boolean
C0021102 (UMLS CUI [1])
C0030163 (UMLS CUI [2])
C0582124 (UMLS CUI [3])
C0524729 (UMLS CUI [4])
C1140609 (UMLS CUI [5])
C0179977 (UMLS CUI [6])
C0005557 (UMLS CUI [7])
C0347948 (UMLS CUI [8])
C0016542 (UMLS CUI [9])
C0542331 (UMLS CUI [10])
C0524724 (UMLS CUI [11])
C0038917 (UMLS CUI [12])
C1961548 (UMLS CUI [13])
Disease Preventing Magnetic Resonance Imaging | Severe Claustrophobia
Item
in the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the mri, such as severe claustrophobia.
boolean
C0012634 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
C0008909 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])